Proteintech

IL18 Monoclonal Antibody (5C6F8)

IL18 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 10

IL18 Antibody (60070-1-IG) in ICC/IF

Immunofluorescent analysis of MCF-7 cells, using IL18 antibody 60070-1-IG at 1:25 dilution and Rhodamine-labeled goat anti-mouse IGG (red).

IL18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IL18 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Product Image Gallery

Product Details

60070-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 16 publications 16 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:1,000

Immunocytochemistry (ICC/IF)

1:10-1:100

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human

Published species

Not Applicable

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

5C6F8

Immunogen

IL18 Fusion Protein Ag1063 (1-193 aa encoded by BC007461)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAAEPVEDN CINFVAMKFI DNTLYFIAED DENLESDYFG KLESKLSVIR NLNDQVLFID QGNRPLFEDM TDSDCRDNAP RTIFIISMYK DSQPRGMAVT ISVKCEKIST LSCENKIISF KEMNPPDNIK DTKSDIIFFQ RSVPGHDNKM QFESSSYEGY FLACEKERDL FKLILKKEDE LGDRSIMFTV QNED (1-193 aa encoded by BC007461)

Target Information

The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein can specifically interact with this cytokine, and thus negatively regulate its biological activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Alpha-kinase1 promotes tubular injury and interstitial inflammation in diabetic nephropathy by canonical pyroptosis pathway.

Biological research

Cui X,Li Y,Yuan S,Huang Y,Chen X,Han Y,Liu Z,Li Z,Xiao Y,Wang Y,Sun L,Liu H,Zhu X

Thu Feb 02 00:00:00 EST 2023

Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK/SIRT1/NF-κB signaling pathway.

International immunopharmacology

He Y,Wang Y,Jia X,Li Y,Yang Y,Pan L,Zhao R,Han Y,Wang F,Guan X,Hou T

Thu Jun 01 00:00:00 EDT 2023

Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK/SIRT1/NF-κB signaling pathway.

International immunopharmacology

He Y,Wang Y,Jia X,Li Y,Yang Y,Pan L,Zhao R,Han Y,Wang F,Guan X,Hou T

Thu Jun 01 00:00:00 EDT 2023

TMBIM4 Deficiency Facilitates NLRP3 Inflammasome Activation-Induced Pyroptosis of Trophoblasts: A Potential Pathogenesis of Preeclampsia.

Biology

Chen Y,Xiao L,Sun G,Li M,Yang H,Ming Z,Zhao K,Shang X,Zhang H,Liu C

Sun Jan 29 00:00:00 EST 2023

The Correlation between Increased Expressions of NLRP3 Inflammasome Components in Peripheral Blood Mono-Nuclear Cells and Plaque Vulnerability in Human Carotid Atherosclerosis.

Iranian journal of public health

Xie W,Shi X,Lee H,Wang L,Niu N,Qu P

Sun Jan 01 00:00:00 EST 2023

Sleep Deprivation Promotes Endothelial Inflammation and Atherogenesis by Reducing Exosomal miR-182-5p.

Arteriosclerosis, thrombosis, and vascular biology

Li X,Cao Y,Xu X,Wang C,Ni Q,Lv X,Yang C,Zhang Z,Qi X,Song G

Thu Jun 01 00:00:00 EDT 2023

MCC950 ameliorates ventricular arrhythmia vulnerability induced by heart failure.

Bioengineered

Jiang X,Yang F,Ou D,Huang L,Li H,Lang M

Fri Apr 01 00:00:00 EDT 2022

GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome.

Journal of neuroinflammation

Qin Z,Song J,Lin A,Yang W,Zhang W,Zhong F,Huang L,Lü Y,Yu W

Fri May 27 00:00:00 EDT 2022

Role of salivary glycopatterns for oral microbiota associated with gastric cancer.

International journal of biological macromolecules

Shu J,Yu H,Ren X,Wang Y,Zhang K,Tang Z,Dang L,Chen W,Li B,Xie H,Li Z

Wed Jun 01 00:00:00 EDT 2022

β-Hydroxybutyrate against Cisplatin-Induced acute kidney injury via inhibiting NLRP3 inflammasome and oxidative stress.

International immunopharmacology

Luo S,Yang M,Han Y,Zhao H,Jiang N,Li L,Chen W,Li C,Yang J,Liu Y,Liu C,Zhao C,Sun L

Sat Oct 01 00:00:00 EDT 2022

METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice.

Cell death discovery

Yang L,Wu G,Wu Q,Peng L,Yuan L

Mon Feb 14 00:00:00 EST 2022

Methamphetamine Disturbs Gut Homeostasis and Reshapes Serum Metabolome, Inducing Neurotoxicity and Abnormal Behaviors in Mice.

Frontiers in microbiology

Zhang KK,Chen LJ,Li JH,Liu JL,Wang LB,Xu LL,Yang JZ,Li XW,Xie XL,Wang Q

Sat May 07 00:00:00 EDT 2022

Aerobic exercise training alleviates renal injury in db/db mice through inhibiting Nox4-mediated NLRP3 inflammasome activation.

Experimental gerontology

Zhou Z,Ying C,Zhou X,Shi Y,Xu J,Zhu Y,Wang M,Li Y,Li X,Xiang J

Sat Oct 15 00:00:00 EDT 2022

Inhibition of Dectin-1 Alleviates Neuroinflammatory Injury by Attenuating NLRP3 Inflammasome-Mediated Pyroptosis After Intracerebral Hemorrhage in Mice: Preliminary Study Results.

Journal of inflammation research

Ding Z,Zhong Z,Wang J,Zhang R,Shao J,Li Y,Wu G,Tu H,Yuan W,Sun H,Wang Q

Tue Nov 01 00:00:00 EDT 2022

Targeted inhibition of the immunoproteasome blocks endothelial MHC class II antigen presentation to CD4⁺ T cells in chronic liver injury.

International immunopharmacology

Zhang Y,Yang X,Bi T,Wu X,Wang L,Ren Y,Ou Y,Xie C,Li K,Ran H,Wang J,Zhao F,Shui P,Qing J

Wed Jun 01 00:00:00 EDT 2022

Cathepsin B/HSP70 complex induced by Ilexsaponin I suppresses NLRP3 inflammasome activation in myocardial ischemia/reperfusion injury.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Wu J,Chen S,Wu P,Wang Y,Qi X,Zhang R,Liu Z,Wang D,Cheng Y

Sat Oct 01 00:00:00 EDT 2022

Tongluo Yishen Decoction Ameliorates Renal Fibrosis via NLRP3-Mediated Pyroptosis In Vivo and In Vitro.

Frontiers in pharmacology

Jia Q,Zhang X,Hao G,Zhao Y,Lowe S,Han L,Qin J

Tue Jul 26 00:00:00 EDT 2022

Tongluo Yishen Decoction Ameliorates Renal Fibrosis via NLRP3-Mediated Pyroptosis In Vivo and In Vitro.

Frontiers in pharmacology

Jia Q,Zhang X,Hao G,Zhao Y,Lowe S,Han L,Qin J

Tue Jul 26 00:00:00 EDT 2022

Exploring Molecular Mechanisms Involved in the Development of the Depression-Like Phenotype in Interleukin-18-Deficient Mice.

BioMed research international

Yamanishi K,Miyauchi M,Mukai K,Hashimoto T,Uwa N,Seino H,Li W,Gamachi N,Hata M,Kuwahara-Otani S,Maeda S,Watanabe Y,Yamanishi H,Yagi H,Okamura H,Matsunaga H

Mon Jan 24 00:00:00 EST 2022

Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer.

International journal of biological sciences

Yan H,Luo B,Wu X,Guan F,Yu X,Zhao L,Ke X,Wu J,Yuan J

Wed Mar 16 00:00:00 EDT 2022

Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer.

International journal of biological sciences

Yan H,Luo B,Wu X,Guan F,Yu X,Zhao L,Ke X,Wu J,Yuan J

Wed Mar 16 00:00:00 EDT 2022

Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway.

Cancer management and research

Luo W,Han Y,Meng P,Yang Q,Zhao H,Ling J,Wang Y

Tue Apr 19 00:00:00 EDT 2022

Endogenous Interleukin 18 Suppresses Liver Regeneration After Hepatectomy in Mice.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Ma T,Zhang Y,Lao M,Chen W,Hu Q,Zhi X,Chen Z,Bai X,Dang X,Liang T

Sun Mar 01 00:00:00 EST 2020

Bioinformatics

Protein Aliases: Iboctadekin; IFN-gamma-inducing factor; il 18; IL-1 gamma; IL-18; ILN; Interferon gamma-inducing factor; Interleukin; interleukin 18 (interferon-gamma-inducing factor); Interleukin-1 gamma; Interleukin-18; Interleukin18; MGC12320

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Gene Aliases: IGIF; IL-18; IL-1g; IL18; IL1F4

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UniProt ID: (Human) Q14116

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Entrez Gene ID: (Human) 3606

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Function(s)

cytokine activity protein binding cytokine interleukin superfamily intercellular signal molecule

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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IL18 Monoclonal Antibody (5C6F8)

IL18 Antibody (60070-1-IG) in ICC/IF

Product Details

60070-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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