Proteintech

PCNA Monoclonal Antibody (10D10E11)

PCNA Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 16

PCNA Antibody (60097-1-IG) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HepG2 cells using 60097-1-IG (PCNA antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IGG (H+L).

PCNA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PCNA Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

60097-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:5,000-1:50,000

View 56 publications 56 publications

Immunohistochemistry (IHC)

View 25 publications 25 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:2,000

Immunocytochemistry (ICC/IF)

1:50-1:500

View 16 publications 16 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Published species

Human, Mouse, Pig, Rabbit

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

10D10E11

Immunogen

PCNA Fusion Protein Ag7416 (8-256 aa encoded by BC000491)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QGSILKKVL EALKDLINEA CWDISSSGVN LQSMDSSHVS LVQLTLRSEG FDTYRCDRNL AMGVNLTSMS KILKCAGNED IITLRAEDNA DTLALVFEAP NQEKVSDYEM KLMDLDVEQL GIPEQEYSCV VKMPSGEFAR ICRDLSHIGD AVVISCAKDG VKFSASGELG NGNIKLSQTS NVDKEEEAVT IEMNEPVQLT FALRYLNFFT KATPLSSTVT LSMSADVPLV VEYKIADMGH LKYYLAPKIE (8-256 aa encoded by BC000491)

Target Information

PCNA (polymerase delta auxiliary protein) is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumor tissue (i.e. relevant to prognosis). PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. PCNA is found in the nucleus and is a cofactor of DNA polymerase delta, and acts as a homotrimer and helps increase the processing of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of PCNA have been described on chromosome 4 and on the X chromosome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Resveratrol improves follicular development of PCOS rats via regulating glycolysis pathway and targeting SIRT1.

Systems biology in reproductive medicine

Huo P,Li M,Le J,Zhu C,Yao J,Zhang S

Sat Apr 01 00:00:00 EDT 2023

MicroRNA-499-5p promotes vascular smooth muscle cell proliferation and migration via inhibiting SOX6.

Physiological genomics

Sheng Y,Yang Z,Feng Z,Wang Y,Ji N

Wed Feb 01 00:00:00 EST 2023

PCNA Staining of Retinal Cryosections to Assess Microglial/Macrophage Proliferation.

Methods in molecular biology (Clifton, N.J.)

Lovel AG,Mitchell DM

Thu Mar 09 00:00:00 EST 2023

Inhibition of tiRNA-Gly-GCC ameliorates neointimal formation via CBX3-mediated VSMCs phenotypic switching.

Frontiers in cardiovascular medicine

Rong Z,Li F,Zhang R,Niu S,Di X,Ni L,Liu C

Fri Feb 24 00:00:00 EST 2023

Inhibition of tiRNA-Gly-GCC ameliorates neointimal formation via CBX3-mediated VSMCs phenotypic switching.

Frontiers in cardiovascular medicine

Rong Z,Li F,Zhang R,Niu S,Di X,Ni L,Liu C

Fri Feb 24 00:00:00 EST 2023

Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice.

Nature communications

Chen Y,Chen L,Wu X,Zhao Y,Wang Y,Jiang D,Liu X,Zhou T,Li S,Wei Y,Liu Y,Hu C,Zhou B,Qin J,Ying H,Ding Q

Sat Mar 18 00:00:00 EDT 2023

Macrophages and derived-TNF-α promote lipopolysaccharide-induced upregulation of endogenous β-glucuronidase in the epithelial cells of the bile duct: A possible facilitator of hepatolithiasis formation.

Clinics and research in hepatology and gastroenterology

Yang Y,Wang Y,Wang C,Wu S,Yao D

Sun Jan 01 00:00:00 EST 2023

RNF112-mediated FOXM1 ubiquitination suppresses the proliferation and invasion of gastric cancer.

JCI insight

Zhang S,Wang J,Hu W,He L,Tang Q,Li J,Jie M,Li X,Liu C,Ouyang Q,Yang S,Hu C

Thu Jun 08 00:00:00 EDT 2023

Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway.

Pharmaceutical biology

Ding J,Lu B,Liu L,Zhong Z,Wang N,Li B,Sheng W,He Q

Fri Dec 01 00:00:00 EST 2023

Experimental Design of Vertical Distraction Osteogenesis Using Simple 3 Screws.

The Journal of craniofacial surgery

Li Z,Jiang D,Yao Y

Mon Jul 10 00:00:00 EDT 2023

Experimental Design of Vertical Distraction Osteogenesis Using Simple 3 Screws.

The Journal of craniofacial surgery

Li Z,Jiang D,Yao Y

Mon Jul 10 00:00:00 EDT 2023

The novel peptide PFAP1 promotes primordial follicle activation by binding to MCM5.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Zhang Y,Wang H,Zhu Y,Hou X,Li X,Zhou X,Ge L,Xu J,Su Y

Mon May 01 00:00:00 EDT 2023

Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice.

Nature communications

Jiang X,Cheng Y,Zhu Y,Xu C,Li Q,Xing X,Li W,Zou J,Meng L,Azhar M,Cao Y,Tong X,Qin W,Zhu X,Bao J

Thu Jun 22 00:00:00 EDT 2023

Grain-sized moxibustion at Zusanli (ST36) promotes hepatic autophagy in rats with hyperlipidemia by regulating the ULK1 and TFEB expression through the AMPK/mTOR signaling pathway.

Heliyon

Xu Q,Wu H,Zhu H,Lu C,Tao J,Zhou Z,Zhang J

Mon May 01 00:00:00 EDT 2023

SNAI2 Attenuated the Stem-like Phenotype by Reducing the Expansion of EPCAM^high Cells in Cervical Cancer Cells.

International journal of molecular sciences

Liu X,Zhang N,Chen Q,Feng Q,Zhang Y,Wang Z,Yue X,Li H,Cui N

Thu Jan 05 00:00:00 EST 2023

Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.

Cell death and differentiation

Zhang G,Jiang C,Yang Y,Wang Y,Zhou H,Dai S,Liu M,Yang Y,Yang L,Shen Q,Zhang T,Zhang X,Yang Y,Shen Y

Wed Feb 01 00:00:00 EST 2023

RNF8 enhances the sensitivity of PD-L1 inhibitor against melanoma through ubiquitination of galectin-3 in stroma.

Cell death discovery

Guo Y,Shen R,Yang K,Wang Y,Song H,Liu X,Cheng X,Wu R,Song Y,Wang D

Fri Jun 30 00:00:00 EDT 2023

Scale-out production of extracellular vesicles derived from natural killer cells via mechanical stimulation in a seesaw-motion bioreactor for cancer therapy.

Biofabrication

Wu J,Wu D,Wu G,Bei HP,Li Z,Xu H,Wang Y,Wu D,Liu H,Shi S,Zhao C,Xu Y,He Y,Li J,Wang C,Zhao X,Wang S

Fri Aug 05 00:00:00 EDT 2022

AGuIX nanoparticles enhance ionizing radiation-induced ferroptosis on tumor cells by targeting the NRF2-GPX4 signaling pathway.

Journal of nanobiotechnology

Sun H,Cai H,Xu C,Zhai H,Lux F,Xie Y,Feng L,Du L,Liu Y,Sun X,Wang Q,Song H,He N,Zhang M,Ji K,Wang J,Gu Y,Leduc G,Doussineau T,Wang Y,Liu Q,Tillement O

Fri Oct 14 00:00:00 EDT 2022

Repression of Mafb promotes foreskin fibroblast proliferation through upregulation of CDK2, cyclin E and PCNA.

Andrologia

Kong X,Liu Z,Long C,Shen L,Liu X,Wei G

Fri Jul 01 00:00:00 EDT 2022

CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.

Experimental eye research

Wang Y,Jin C,Tian H,Xu J,Chen J,Hu S,Li Q,Lu L,Ou Q,Xu GT,Cui H

Wed Jun 01 00:00:00 EDT 2022

Diterpenoids from the whole plant of Euphorbia wallichii and their protective effects on H₂O₂-induced BV-2 microglial cells injury.

Bioorganic chemistry

Wang Y,Zhu M,Liang J,Zhang N,Sun D,Li H,Chen L

Tue Nov 01 00:00:00 EDT 2022

Morphological changes of macrophages and their potential contribution to tendon healing.

Colloids and surfaces. B, Biointerfaces

Yang QQ,Zhang L,Zhou YL,Tang JB

Sat Jan 01 00:00:00 EST 2022

Keloid Nodule Metabolic Activity for Continuous Expansion.

Plastic and reconstructive surgery. Global open

Ueda K,Lee Y,Inomata Y,Taniguchi K,Uchiyama K,Ito Y

Mon Aug 01 00:00:00 EDT 2022

LncRNA SNHG16 accelerates atherosclerosis and promotes ox-LDL-induced VSMC growth via the miRNA-22-3p/HMGB2 axis.

European journal of pharmacology

Wang Y,Yang Y,Zhang T,Jia S,Ma X,Zhang M,Wang L,Ma A

Sat Jan 15 00:00:00 EST 2022

LncRNA LINC00281/Annexin A2 Regulates Vascular Smooth Muscle Cell Phenotype Switching via the Nuclear Factor-Kappa B Signaling Pathway.

Journal of cardiovascular translational research

Cheng L,Wang H,Maboh R,Mao G,Wu X,Chen H

Sat Oct 01 00:00:00 EDT 2022

Omentin-1 promoted proliferation and ameliorated inflammation, apoptosis, and degeneration in human nucleus pulposus cells.

Archives of gerontology and geriatrics

Cabral VLF,Wang F,Peng X,Gao J,Zhou Z,Sun R,Bao J,Wu X

Tue Jul 12 00:00:00 EDT 2022

Integrated analysis of tRNA-derived small RNAs in proliferative human aortic smooth muscle cells.

Cellular & molecular biology letters

Zhao JZ,Li QY,Lin JJ,Yang LY,Du MY,Wang Y,Liu KX,Jiang ZA,Li HH,Wang SF,Sun B,Mu SQ,Li B,Liu K,Gong M,Sun SG

Wed Jun 15 00:00:00 EDT 2022

Hoxa5 inhibits adipocyte proliferation through transcriptional regulation of Ccne1 and blocking JAK2/STAT3 signaling pathway in mice.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Pan M,Sun Q,Li C,Tai R,Shi X,Sun C

Mon Aug 01 00:00:00 EDT 2022

Epoxyeicosatrienoic Acids Inhibit the Activation of Murine Fibroblasts by Blocking the TGF-β1-Smad2/3 Signaling in a PPARγ-Dependent Manner.

Oxidative medicine and cellular longevity

Tao JH,Liu T,Zhang CY,Zu C,Yang HH,Liu YB,Yang JT,Zhou Y,Guan CX

Thu Oct 27 00:00:00 EDT 2022

Differential regulatory roles of microRNAs during intramuscular adipogenesis in Chinese Guizhou Congjiang Xiang pigs.

Epigenetics

Tan L,Chen Z,Ruan Y,Xu H

Thu Dec 01 00:00:00 EST 2022

Antioxidant potential of Pediococcus pentosaceus strains from the sow milk bacterial collection in weaned piglets.

Microbiome

Wang L,Liu Q,Chen Y,Zheng X,Wang C,Qi Y,Dong Y,Xiao Y,Chen C,Chen T,Huang Q,Zhai Z,Long C,Yang H,Li J,Wang L,Zhang G,Liao P,Liu YX,Huang P,Huang J,Wang Q,Chu H,Yin J,Yin Y

Wed Jun 01 00:00:00 EDT 2022

Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway.

International journal of molecular sciences

Yang G,Lu S,Jiang J,Weng J,Zeng X

Fri May 27 00:00:00 EDT 2022

Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway.

International journal of molecular sciences

Yang G,Lu S,Jiang J,Weng J,Zeng X

Fri May 27 00:00:00 EDT 2022

Alpha1B-adreneroceptor is involved in norepinephrine-induced pulmonary artery smooth muscle cell proliferation via p38 signaling.

European journal of pharmacology

Xiao X,Zhang Y,Tian S,Wang X,Zhang Q,Zhang L,Yu X,Ma C,Zheng X,Li Y,Zhang J,Qu L

Thu Sep 15 00:00:00 EDT 2022

Effects of nanoparticle-mediated Co-delivery of bFGF and VEGFA genes to deep burn wounds: An in vivo study.

Colloids and surfaces. B, Biointerfaces

Zhang Q,Zhang C,Feng L,Wang L,Qi J,Dong Y,Zhou YL,Hu K,Zhang Y

Sat Jan 01 00:00:00 EST 2022

Effects of nanoparticle-mediated Co-delivery of bFGF and VEGFA genes to deep burn wounds: An in vivo study.

Colloids and surfaces. B, Biointerfaces

Zhang Q,Zhang C,Feng L,Wang L,Qi J,Dong Y,Zhou YL,Hu K,Zhang Y

Sat Jan 01 00:00:00 EST 2022

PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.

Experimental dermatology

Tao T,Chen Y,Chen J,Lian C,Xu S,Zhang M,Fang C

Mon Aug 01 00:00:00 EDT 2022

Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy.

Cell and tissue research

Bian Y,Shi C,Song S,Mu L,Wu M,Qiu D,Dong J,Zhang W,Yuan C,Wang D,Zhou Z,Dong X,Shi Y

Sat Oct 01 00:00:00 EDT 2022

Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy.

Cell and tissue research

Bian Y,Shi C,Song S,Mu L,Wu M,Qiu D,Dong J,Zhang W,Yuan C,Wang D,Zhou Z,Dong X,Shi Y

Sat Oct 01 00:00:00 EDT 2022

Dhh signaling pathway regulates reconstruction of seminiferous tubule-like structure.

Reproductive biology

Min M,Song T,Sun M,Wang T,Tan J,Zhang J

Thu Dec 01 00:00:00 EST 2022

Capsaicin suppresses hepatocarcinogenesis by inhibiting the stemness of hepatic progenitor cells via SIRT1/SOX2 signaling pathway.

Cancer medicine

Xie ZQ,Li HX,Hou XJ,Huang MY,Zhu ZM,Wei LX,Tang CX

Tue Nov 01 00:00:00 EDT 2022

PTP70-2, a novel polysaccharide from Polygala tenuifolia, prevents neuroinflammation and protects neurons by suppressing the TLR4-mediated MyD88/NF-κB signaling pathway.

International journal of biological macromolecules

Chen H,Zhong J,Li J,Zeng Z,Yu Q,Yan C

Sat Jan 01 00:00:00 EST 2022

Photodynamic Therapy by Glucose Transporter 1-Selective Light Inactivation.

ACS omega

Miura K,Wen Y,Tsushima M,Nakamura H

Tue Sep 27 00:00:00 EDT 2022

Chitosan degradation products promote healing of burn wounds of rat skin.

Frontiers in bioengineering and biotechnology

Zhang C,Zhang Q,Yang D,Qiao Y,Wang B,Yan J,Li Z,Huang Z,Zhou Y,Hu K,Zhang Y

Sat Oct 29 00:00:00 EDT 2022

Opposite Roles of Tumor Cell Proliferation and Immune Cell Infiltration in Postoperative Liver Metastasis of PDAC.

Frontiers in cell and developmental biology

Wang G,Dai S,Gao H,Gao Y,Yin L,Zhang K,Huang X,Lu Z,Miao Y

Tue Apr 26 00:00:00 EDT 2022

Aldolase A and Phospholipase D1 Synergistically Resist Alkylating Agents and Radiation in Lung Cancer.

Frontiers in oncology

Chang YC,Chang PM,Li CH,Chan MH,Lee YJ,Chen MH,Hsiao M

Tue Feb 08 00:00:00 EST 2022

Reticulocalbin 1 is required for proliferation and migration of non-small cell lung cancer cells regulated by osteoblast-conditioned medium.

Journal of cellular and molecular medicine

Fu H,Chen R,Wang Y,Xu Y,Xia C,Zhang B

Wed Dec 01 00:00:00 EST 2021

Sunitinib malate inhibits intestinal tumor development in male Apc^Min/+ mice by down-regulating inflammation-related factors with suppressing β-cateinin/c-Myc pathway and re-balancing Bcl-6 and Caspase-3.

International immunopharmacology

Chen L,Xu P,Xiao Q,Chen L,Li S,Jian JM,Zhong YB

Fri Jan 01 00:00:00 EST 2021

Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells.

International journal of biological sciences

Liu Y,Shi C,He Z,Zhu F,Wang M,He R,Zhao C,Shi X,Zhou M,Pan S,Gao Y,Li X,Qin R

Mon Jan 03 00:00:00 EST 2022

Acyl-CoA Thioesterase 7 is Transcriptionally Activated by Krüppel-Like Factor 13 and Promotes the Progression of Hepatocellular Carcinoma.

Journal of hepatocellular carcinoma

Xie X,Chen C,Feng S,Zuo S,Zhao X,Li H

Fri Apr 29 00:00:00 EDT 2022

Vaccination with Polyclonal Antibody Stimulator (PAS) Prevents Pancreatic Carcinogenesis in the KRAS Mouse Model.

Cancer prevention research (Philadelphia, Pa.)

Smith JP,Cao H,Chen W,Kallakury B,Phillips T,Sutton L,Cato A

Fri Oct 01 00:00:00 EDT 2021

The combination of G-CSF and AMD3100 mobilizes bone marrow-derived stem cells to protect against cisplatin-induced acute kidney injury in mice.

Stem cell research & therapy

Chen Z,Ren X,Ren R,Wang Y,Shang J

Wed Mar 24 00:00:00 EDT 2021

Yixintongmai Inhibits Proliferation and Migration and Promotes Apoptosis of Vascular Smooth Muscle Cells Cultured with High Glucose.

Evidence-based complementary and alternative medicine : eCAM

Guo J,Zhao D,Dong P

Sat Apr 23 00:00:00 EDT 2022

Hsa_circ_0076305 induces migration-proliferation dichotomy in gastric cancer.

Oncology letters

Zhang Y,Hong Y,Wang D,Duan L,Liu Y,Li L,Liu D,Zhuang K,Wei C,Zheng G,Huo C,Liu G

Mon Mar 01 00:00:00 EST 2021

High fat suppresses SOD1 activity by reducing copper chaperone for SOD1 associated with neurodegeneration and memory decline.

Life sciences

Lu P,Yan HJ,Yang C,Feng WC,Hu F,Wu YY,Sun WW,Gao MM,Long YS

Sat May 01 00:00:00 EDT 2021

Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway.

Cell death & disease

Fang S,Wan X,Zou X,Sun S,Hao X,Liang C,Zhang Z,Zhang F,Sun B,Li H,Yu B

Mon Jan 18 00:00:00 EST 2021

Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions.

iScience

Chen X,Zhang Y,Qian W,Han L,Li W,Duan W,Wu Z,Wang Z,Ma Q

Fri Dec 17 00:00:00 EST 2021

FOXO1 mediates hypoxia-induced G0/G1 arrest in ovarian somatic granulosa cells by activating the TP53INP1-p53-CDKN1A pathway.

Development (Cambridge, England)

Li C,Liu Z,Wu G,Zang Z,Zhang JQ,Li X,Tao J,Shen M,Liu H

Thu Jul 15 00:00:00 EDT 2021

Protective effects and mechanisms of high-dose vitamin C on sepsis-associated cognitive impairment in rats.

Scientific reports

Zhang N,Zhao W,Hu ZJ,Ge SM,Huo Y,Liu LX,Gao BL

Thu Jul 15 00:00:00 EDT 2021

CENPE contributes to pulmonary vascular remodeling in pulmonary hypertension.

Biochemical and biophysical research communications

Fang X,Xie M,Liu X,He Y

Fri Jun 11 00:00:00 EDT 2021

Asenapine maleate inhibits angiotensin II-induced proliferation and activation of cardiac fibroblasts via the ROS/TGFβ1/MAPK signaling pathway.

Biochemical and biophysical research communications

Wu HH,Meng TT,Chen JM,Meng FL,Wang SY,Liu RH,Chen JN,Ning B,Li Y,Su GH

Fri May 14 00:00:00 EDT 2021

CCNB1 Expedites the Progression of Cervical Squamous Cell Carcinoma via the Regulation by FOXM1.

OncoTargets and therapy

Li S,Liu N,Piao J,Meng F,Li Y

Mon Oct 24 00:00:00 EDT 2022

Elevated expression of minichromosome maintenance 3 indicates poor outcomes and promotes G1/S cell cycle progression, proliferation, migration and invasion in colorectal cancer.

Bioscience reports

Zhou H,Xiong Y,Zhang G,Liu Z,Li L,Hou S,Zhou T

Fri Jul 31 00:00:00 EDT 2020

Mixed micelles of TPGS and Soluplus^® for co-delivery of paclitaxel and fenretinide: in vitro and in vivo anticancer study.

Pharmaceutical development and technology

Wang Y,Ding Y,Xu Y,Wang C,Ding Y,Gao M,Ma C,Ma X,Li L

Tue Sep 01 00:00:00 EDT 2020

Succinylation at a key residue of FEN1 is involved in the DNA damage response to maintain genome stability.

American journal of physiology. Cell physiology

Shi R,Wang Y,Gao Y,Xu X,Mao S,Xiao Y,Song S,Wang L,Tian B,Zhao Y,Hua Y,Xu H

Thu Oct 01 00:00:00 EDT 2020

Apatinib suppresses tumor progression and enhances cisplatin sensitivity in esophageal cancer via the Akt/β-catenin pathway.

Cancer cell international

Wei B,Wang Y,Wang J,Cai X,Xu L,Wu J,Wang Y,Liu W,Gu Y,Guo W,Xu Q

Thu Apr 14 00:00:00 EDT 2022

PCNA and GSK3β interact with each other to regulate H1299 lung adenocarcinoma cells apoptosis.

Neoplasma

Liu XH,Tang DE,Dai Y,Gao XJ,Liu LX

Wed Jan 01 00:00:00 EST 2020

PCNA and GSK3β interact with each other to regulate H1299 lung adenocarcinoma cells apoptosis.

Neoplasma

Liu XH,Tang DE,Dai Y,Gao XJ,Liu LX

Wed Jan 01 00:00:00 EST 2020

PCNA and GSK3β interact with each other to regulate H1299 lung adenocarcinoma cells apoptosis.

Neoplasma

Liu XH,Tang DE,Dai Y,Gao XJ,Liu LX

Wed Jan 01 00:00:00 EST 2020

Silencing ARAF Suppresses the Malignant Phenotypes of Gallbladder Cancer Cells.

BioMed research international

Lin W,Tong C,Zhang W,Cen W,Wang Y,Li J,Zhu Z,Yu J,Lu B

Thu Apr 29 00:00:00 EDT 2021

A Novel Antitumor Strategy: Simultaneously Inhibiting Angiogenesis and Complement by Targeting VEGFA/PIGF and C3b/C4b.

Molecular therapy oncolytics

Wang H,Li Y,Shi G,Wang Y,Lin Y,Wang Q,Zhang Y,Yang Q,Dai L,Cheng L,Su X,Yang Y,Zhang S,Li Z,Li J,Wei Y,Yu D,Deng H

Fri Mar 27 00:00:00 EDT 2020

The tacrolimus-induced glucose homeostasis imbalance in terms of the liver: From bench to bedside.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Ling Q,Huang H,Han Y,Zhang C,Zhang X,Chen K,Wu L,Tang R,Zheng Z,Zheng S,Li L,Wang B

Sun Mar 01 00:00:00 EST 2020

Effect of Quercetin on PC12 Alzheimer's Disease Cell Model Induced by Aβ _25-35 and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway.

BioMed research international

Yu X,Li Y,Mu X

Wed Feb 10 00:00:00 EST 2021

Dihydroartemisinin and doxorubicin co-loaded Soluplus^®-TPGS mixed micelles: formulation characterization, cellular uptake, and pharmacodynamic studies.

Pharmaceutical development and technology

Wang Y,Ding Y,Zhao J,Wang C,Gao M,Chi X,Zhang B,Ma X,Li L

Fri Nov 01 00:00:00 EDT 2019

HOXC13-AS promotes breast cancer cell growth through regulating miR-497-5p/PTEN axis.

Journal of cellular physiology

Li X,Wang Q,Rui Y,Zhang C,Wang W,Gu J,Tang J,Ding Y

Sun Dec 01 00:00:00 EST 2019

MicroRNA-221 sensitizes chronic myeloid leukemia cells to imatinib by targeting STAT5.

Leukemia & lymphoma

Jiang X,Cheng Y,Hu C,Zhang A,Ren Y,Xu X

Mon Jul 01 00:00:00 EDT 2019

MicroRNA-221 sensitizes chronic myeloid leukemia cells to imatinib by targeting STAT5.

Leukemia & lymphoma

Jiang X,Cheng Y,Hu C,Zhang A,Ren Y,Xu X

Mon Jul 01 00:00:00 EDT 2019

Early Histone Deacetylase Inhibition Mitigates Ischemia/Reperfusion Brain Injury by Reducing Microglia Activation and Modulating Their Phenotype.

Frontiers in neurology

Li S,Lu X,Shao Q,Chen Z,Huang Q,Jiao Z,Huang X,Yue M,Peng J,Zhou X,Chao D,Zhao H,Ji J,Ji Y,Ji Q

Thu Oct 01 00:00:00 EDT 2020

Resistin-Inhibited Neural Stem Cell-Derived Astrocyte Differentiation Contributes to Permeability Destruction of the Blood-Brain Barrier.

Neurochemical research

Xiaoying L,Li T,Yu S,Jiusheng J,Jilin Z,Jiayi W,Dongxin L,Wengang F,Xinyue Z,Hao Y,Yuhua C,Deshu S

Mon Apr 01 00:00:00 EDT 2019

Bradykinin potentially stimulates cell proliferation in rabbit corneal endothelial cells through the ZO‑1/ZONAB pathway.

International journal of molecular medicine

He L,Zhou Z,Shao Y,Yang Z,Zhou S,Zou X,Zhou Y,Tan G

Sun Jul 01 00:00:00 EDT 2018

Bradykinin potentially stimulates cell proliferation in rabbit corneal endothelial cells through the ZO‑1/ZONAB pathway.

International journal of molecular medicine

He L,Zhou Z,Shao Y,Yang Z,Zhou S,Zou X,Zhou Y,Tan G

Sun Jul 01 00:00:00 EDT 2018

Identification of G2/M phase transition by sequential nuclear and cytoplasmic changes and molecular markers in mice intestinal epithelial cells.

Cell cycle (Georgetown, Tex.)

Ren J,Tang CZ,Li XD,Niu ZB,Zhang BY,Zhang T,Gao MJ,Ran XZ,Su YP,Wang FC

Tue Sep 10 00:00:00 EDT 2019

Identification of G2/M phase transition by sequential nuclear and cytoplasmic changes and molecular markers in mice intestinal epithelial cells.

Cell cycle (Georgetown, Tex.)

Ren J,Tang CZ,Li XD,Niu ZB,Zhang BY,Zhang T,Gao MJ,Ran XZ,Su YP,Wang FC

Tue Sep 10 00:00:00 EDT 2019

Prenatal influenza vaccination rescues impairments of social behavior and lamination in a mouse model of autism.

Journal of neuroinflammation

Wu Y,Qi F,Song D,He Z,Zuo Z,Yang Y,Liu Q,Hu S,Wang X,Zheng X,Yang J,Yuan Q,Zou J,Guo K,Yao Z

Mon Aug 13 00:00:00 EDT 2018

Prenatal influenza vaccination rescues impairments of social behavior and lamination in a mouse model of autism.

Journal of neuroinflammation

Wu Y,Qi F,Song D,He Z,Zuo Z,Yang Y,Liu Q,Hu S,Wang X,Zheng X,Yang J,Yuan Q,Zou J,Guo K,Yao Z

Mon Aug 13 00:00:00 EDT 2018

Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing.

Nature communications

Sheng C,Yao C,Wang Z,Chen H,Zhao Y,Xu D,Huang H,Huang W,Chen S

Mon Oct 22 00:00:00 EDT 2018

Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing.

Nature communications

Sheng C,Yao C,Wang Z,Chen H,Zhao Y,Xu D,Huang H,Huang W,Chen S

Mon Oct 22 00:00:00 EDT 2018

USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization.

Nature communications

Yang S,Liu L,Cao C,Song N,Wang Y,Ma S,Zhang Q,Yu N,Ding X,Yang F,Tian S,Zhang K,Sun T,Yang J,Yao Z,Wu S,Shi L

Thu Mar 29 00:00:00 EDT 2018

USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization.

Nature communications

Yang S,Liu L,Cao C,Song N,Wang Y,Ma S,Zhang Q,Yu N,Ding X,Yang F,Tian S,Zhang K,Sun T,Yang J,Yao Z,Wu S,Shi L

Thu Mar 29 00:00:00 EDT 2018

Cellular communication promotes mammosphere growth and collective invasion through microtubule‑like structures and angiogenesis.

Oncology reports

Huang S,Yuan N,Wang G,Wu F,Feng L,Luo M,Li M,Luo A,Zhao X,Zhang L

Sat Dec 01 00:00:00 EST 2018

Role of p38-MAPK pathway in the effects of high-magnitude compression on nucleus pulposus cell senescence in a disc perfusion culture.

Bioscience reports

Pang L,Li P,Zhang R,Xu Y,Song L,Zhou Q

Tue Oct 31 00:00:00 EDT 2017

Role of p38-MAPK pathway in the effects of high-magnitude compression on nucleus pulposus cell senescence in a disc perfusion culture.

Bioscience reports

Pang L,Li P,Zhang R,Xu Y,Song L,Zhou Q

Tue Oct 31 00:00:00 EDT 2017

The Protective Effect of N-Acetylcysteine on Ionizing Radiation Induced Ovarian Failure and Loss of Ovarian Reserve in Female Mouse.

BioMed research international

Gao W,Liang JX,Ma C,Dong JY,Yan Q

Wed Mar 14 00:00:00 EDT 2018

The Protective Effect of N-Acetylcysteine on Ionizing Radiation Induced Ovarian Failure and Loss of Ovarian Reserve in Female Mouse.

BioMed research international

Gao W,Liang JX,Ma C,Dong JY,Yan Q

Wed Mar 14 00:00:00 EDT 2018

The Protective Effect of N-Acetylcysteine on Ionizing Radiation Induced Ovarian Failure and Loss of Ovarian Reserve in Female Mouse.

BioMed research international

Gao W,Liang JX,Ma C,Dong JY,Yan Q

Wed Mar 14 00:00:00 EDT 2018

The Protective Effect of N-Acetylcysteine on Ionizing Radiation Induced Ovarian Failure and Loss of Ovarian Reserve in Female Mouse.

BioMed research international

Gao W,Liang JX,Ma C,Dong JY,Yan Q

Wed Mar 14 00:00:00 EDT 2018

iTRAQ-based Proteomic Analysis of Porcine Kidney Epithelial PK15 cells Infected with Pseudorabies virus.

Scientific reports

Yang S,Pei Y,Zhao A

Tue Apr 04 00:00:00 EDT 2017

iTRAQ-based Proteomic Analysis of Porcine Kidney Epithelial PK15 cells Infected with Pseudorabies virus.

Scientific reports

Yang S,Pei Y,Zhao A

Tue Apr 04 00:00:00 EDT 2017

Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway.

International journal of biological sciences

Han F,Xue M,Chang Y,Li X,Yang Y,Sun B,Chen L

Mon Jun 25 00:00:00 EDT 2018

Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway.

International journal of biological sciences

Han F,Xue M,Chang Y,Li X,Yang Y,Sun B,Chen L

Mon Jun 25 00:00:00 EDT 2018

Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway.

International journal of biological sciences

Han F,Xue M,Chang Y,Li X,Yang Y,Sun B,Chen L

Mon Jun 25 00:00:00 EDT 2018

Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway.

International journal of biological sciences

Han F,Xue M,Chang Y,Li X,Yang Y,Sun B,Chen L

Mon Jun 25 00:00:00 EDT 2018

Effects of resveratrol on ARPE-19 cell proliferation and migration via regulating the expression of proliferating cell nuclear antigen, P21, P27 and p38MAPK/MMP-9.

International journal of ophthalmology

Hao XN,Wang WJ,Chen J,Zhou Q,Qu YX,Liu XY,Xu W

Thu Oct 01 00:00:00 EDT 2020

Effects of resveratrol on ARPE-19 cell proliferation and migration via regulating the expression of proliferating cell nuclear antigen, P21, P27 and p38MAPK/MMP-9.

International journal of ophthalmology

Hao XN,Wang WJ,Chen J,Zhou Q,Qu YX,Liu XY,Xu W

Thu Oct 01 00:00:00 EDT 2020

Enhancement of anti-tumor effects of 5-fluorouracil on hepatocellular carcinoma by low-intensity ultrasound.

Journal of experimental & clinical cancer research : CR

Hu Z,Lv G,Li Y,Li E,Li H,Zhou Q,Yang B,Cao W

Fri Apr 22 00:00:00 EDT 2016

Enhancement of anti-tumor effects of 5-fluorouracil on hepatocellular carcinoma by low-intensity ultrasound.

Journal of experimental & clinical cancer research : CR

Hu Z,Lv G,Li Y,Li E,Li H,Zhou Q,Yang B,Cao W

Fri Apr 22 00:00:00 EDT 2016

NKD1 correlates with a poor prognosis and inhibits cell proliferation by inducing p53 expression in hepatocellular carcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Zhang S,Li J,Wang X

Sat Oct 01 00:00:00 EDT 2016

NKD1 correlates with a poor prognosis and inhibits cell proliferation by inducing p53 expression in hepatocellular carcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Zhang S,Li J,Wang X

Sat Oct 01 00:00:00 EDT 2016

NKD1 correlates with a poor prognosis and inhibits cell proliferation by inducing p53 expression in hepatocellular carcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Zhang S,Li J,Wang X

Sat Oct 01 00:00:00 EDT 2016

NKD1 correlates with a poor prognosis and inhibits cell proliferation by inducing p53 expression in hepatocellular carcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Zhang S,Li J,Wang X

Sat Oct 01 00:00:00 EDT 2016

5-Aminolevulinic acid-mediated sonodynamic therapy induces anti-tumor effects in malignant melanoma via p53-miR-34a-Sirt1 axis.

Journal of dermatological science

Hu Z,Fan H,Lv G,Zhou Q,Yang B,Zheng J,Cao W

Sat Aug 01 00:00:00 EDT 2015

Antisense long non-coding RNA PCNA-AS1 promotes tumor growth by regulating proliferating cell nuclear antigen in hepatocellular carcinoma.

Cancer letters

Yuan SX,Tao QF,Wang J,Yang F,Liu L,Wang LL,Zhang J,Yang Y,Liu H,Wang F,Sun SH,Zhou WP

Thu Jul 10 00:00:00 EDT 2014

Antisense long non-coding RNA PCNA-AS1 promotes tumor growth by regulating proliferating cell nuclear antigen in hepatocellular carcinoma.

Cancer letters

Yuan SX,Tao QF,Wang J,Yang F,Liu L,Wang LL,Zhang J,Yang Y,Liu H,Wang F,Sun SH,Zhou WP

Thu Jul 10 00:00:00 EDT 2014

CXXC5 Associates with Smads to Mediate TNF-α Induced Apoptosis.

Current molecular medicine

Wang X,Liao P,Fan X,Wan Y,Wang Y,Li Y,Jiang Z,Ye X,Mo X,Ocorr K,Deng Y,Wu X,Yuan W

Sun Sep 01 00:00:00 EDT 2013

CXXC5 Associates with Smads to Mediate TNF-α Induced Apoptosis.

Current molecular medicine

Wang X,Liao P,Fan X,Wan Y,Wang Y,Li Y,Jiang Z,Ye X,Mo X,Ocorr K,Deng Y,Wu X,Yuan W

Sun Sep 01 00:00:00 EDT 2013

BMP-6 inhibits cell proliferation by targeting microRNA-192 in breast cancer.

Biochimica et biophysica acta

Hu F,Meng X,Tong Q,Liang L,Xiang R,Zhu T,Yang S

Sun Dec 01 00:00:00 EST 2013

BMP-6 inhibits cell proliferation by targeting microRNA-192 in breast cancer.

Biochimica et biophysica acta

Hu F,Meng X,Tong Q,Liang L,Xiang R,Zhu T,Yang S

Sun Dec 01 00:00:00 EST 2013

Bioinformatics

Protein Aliases: Cyclin; DNA polymerase delta auxiliary protein; HGCN8729; MGC8367; PCNA; Proliferating cell nuclear antigen

View more View less

Gene Aliases: ATLD2; PCNA; Pcna/cyclin; PCNAR

View more View less

UniProt ID: (Human) P12004, (Rat) P04961, (Mouse) P17918

View more View less

Entrez Gene ID: (Pig) 692192, (Human) 5111, (Rat) 25737, (Mouse) 18538

View more View less

Function(s)

purine-specific mismatch base pair DNA N-glycosylase activity chromatin binding damaged DNA binding protein binding enzyme binding estrogen receptor binding DNA polymerase processivity factor activity receptor tyrosine kinase binding dinucleotide insertion or deletion binding MutLalpha complex binding histone acetyltransferase binding identical protein binding DNA polymerase binding transcription factor binding DNA binding DNA polymerase processivity factor

Process(es)

G1/S transition of mitotic cell cycle regulation of transcription involved in G1/S transition of mitotic cell cycle telomere maintenance via recombination telomere maintenance DNA strand elongation involved in DNA replication leading strand elongation transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, DNA gap filling mismatch repair DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest heart development cell proliferation protein sumoylation translesion synthesis epithelial cell differentiation replication fork processing positive regulation of deoxyribonuclease activity nucleotide-excision repair, DNA incision response to lipid cellular response to UV error-prone translesion synthesis DNA damage response, detection of DNA damage positive regulation of DNA repair positive regulation of DNA replication response to cadmium ion error-free translesion synthesis mitotic telomere maintenance via semi-conservative replication negative regulation of transcription from RNA polymerase II promoter regulation of DNA replication base-excision repair, gap-filling cellular response to xenobiotic stimulus DNA replication DNA repair cellular response to DNA damage stimulus regulation of catalytic activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

PCNA Monoclonal Antibody (10D10E11)

PCNA Antibody (60097-1-IG) in ICC/IF

Product Details

60097-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!