Proteintech

peroxiredoxin 2 Monoclonal Antibody (3H6C4)

peroxiredoxin 2 Antibody in Immunocytochemistry (ICC/IF)

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peroxiredoxin 2 Antibody (60202-1-IG) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed MCF-7 cells using 60202-1-IG (peroxiredoxin 2 antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IGG (H+L).

peroxiredoxin 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

peroxiredoxin 2 Antibody in Western Blot (WB)

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Product Details

60202-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

3H6C4

Immunogen

peroxiredoxin 2 Fusion Protein Ag0835 (1-198 aa encoded by BC003022)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MASGNARIG KPAPDFKATA VVDGAFKEVK LSDYKGKYVV LFFYPLDFTF VCPTEIIAFS NRAEDFRKLG CEVLGVSVDS QFTHLAWINT PRKEGGLGPL NIPLLADVTR RLSEDYGVLK TDEGIAYRGL FIIDGKGVLR QITVNDLPVG RSVDEALRLV QAFQYTDEHG EVCPAGWKPG SDTIKPNVDD SKEYFSKHN (1-198 aa encoded by BC003022 )

Target Information

Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 - 30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Peroxiredoxins and Hypoxia-Inducible Factor-1α in Duodenal Tissue: Emerging Factors in the Pathophysiology of Pediatric Celiac Disease Patients.

Current issues in molecular biology

Köse FA,Pabuccuoglu A,Karakoyun M,Aydogdu S

Mon Feb 20 00:00:00 EST 2023

PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53.

Cell death & disease

Wang W,Wei J,Zhang H,Zheng X,Zhou H,Luo Y,Yang J,Deng Q,Huang S,Fu Z

Fri Jun 11 00:00:00 EDT 2021

siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway.

Cancer management and research

Ma Y,Guan L,Han Y,Zhou Y,Li X,Liu Y,Zhang X,Zhang W,Li X,Wang S,Lu W

Thu Oct 01 00:00:00 EDT 2020

Compound kushen injection suppresses human acute myeloid leukaemia by regulating the Prdxs/ROS/Trx1 signalling pathway.