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Product Details
66314-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1E4F1
Immunogen
RSPO3 Fusion Protein Ag9899 (27-272 aa encoded by BC022367)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GRRQRRMHP NVSQGCQGGC ATCSDYNGCL SCKPRLFFAL ERIGMKQIGV CLSSCPSGYY GTRYPDINKC TKCKADCDTC FNKNFCTKCK SGFYLHLGKC LDNCPEGLEA NNHTMECVSI VHCEVSEWNP WSPCTKKGKT CGFKRGTETR VREIIQHPSA KGNLCPPTNE TRKCTVQRKK CQKGERGKKG RERKRKKPNK GESKEAIPDS KSLESSKEIP EQRENKQQQK KRKVQDKQKS VSVSTVH (27-272 aa encoded by BC022367)
Target Information
RSPO3 is a member of the R-spondin family and plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. RSPO3 has been shown to be involved in regulating the balance between angioblast and blood cell specification during embryonic vasculogenesis and angiogenesis and may be involved in tumor development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hPWTSR; hRspo3; Protein with TSP type-1 repeat; R-spondin 3 homolog; R-spondin-3; Roof plate-specific spondin-3; Thrombospondin type-1 domain-containing protein 2; thrombospondin, type I, domain containing 2
Gene Aliases: CRISTIN1; PWTSR; RSPO3; THSD2
UniProt ID: (Human) B2RC27
Entrez Gene ID: (Human) 84870
blood vessel remodeling
sprouting angiogenesis
Wnt signaling pathway
positive regulation of Wnt signaling pathway
branching involved in labyrinthine layer morphogenesis
positive regulation of canonical Wnt signaling pathway
positive regulation of non-canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway, planar cell polarity pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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