Proteintech

SOD2 Monoclonal Antibody (3A6C2)

SOD2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SOD2 Antibody (66474-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using (Product # 66474-1-IG) (SOD2 antibody) at dilution of 1:5,000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

66474-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:10,000-1:40,000

View 26 publications 26 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:600

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Published species

Not Applicable

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

3A6C2

Immunogen

SOD2 Fusion Protein Ag21388 (1-222 aa encoded by BC016934)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLSRAVCGT SRQLAPALGY LGSRQKHSLP DLPYDYGALE PHINAQIMQL HHSKHHAAYV NNLNVTEEKY QEALAKGRFQ AERREAVPGR GDPREPGPIR TGLSVEENSL RICTGSEFSR HDSLSFKHMV YLIVEGVPRW V (1-222 aa encoded by BC016934)

Target Information

Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu, Zn-SOD (EC-SOD/SOD-3). SOD1 is found in all eukaryotic species as a homodimeric 32 kDa enzyme containing one each of Cu and Zn ion per subunit. The manganese containing 80 kDa tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain. SOD3 is a heparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways. SOD4 is a copper chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Pharmacologic Activation of Angiotensin-Converting Enzyme II Alleviates Diabetic Cardiomyopathy in db/db Mice by Reducing Reactive Oxidative Stress.

Diabetes & metabolism journal

Kim D,Jeong W,Kim Y,Lee J,Cho SW,Oh CM,Park R

Sat Jul 01 00:00:00 EDT 2023

Apoptotic vesicles resist oxidative damage in noise-induced hearing loss through activation of FOXO3a-SOD2 pathway.

Stem cell research & therapy

Huang X,Kou X,Zhan T,Wei G,He F,Mao X,Yang H

Sat Apr 15 00:00:00 EDT 2023

Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells.

Journal of ethnopharmacology

Liu J,Yang Y,He Y,Feng C,Ou H,Yang J,Chen Y,You F,Shao B,Bao J,Guan X,Chen F,Zhao P

Sat Mar 25 00:00:00 EDT 2023

A Bioinspired Manganese-Organic Framework Ameliorates Ischemic Stroke through its Intrinsic Nanozyme Activity and Upregulating Endogenous Antioxidant Enzymes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Wang J,Wang Y,Xiaohalati X,Su Q,Liu J,Cai B,Yang W,Wang Z,Wang L

Sat Jul 01 00:00:00 EDT 2023

Energy stress modulation of AMPK/FoxO3 signaling inhibits mitochondria-associated ferroptosis.

Redox biology

Zhong S,Chen W,Wang B,Gao C,Liu X,Song Y,Qi H,Liu H,Wu T,Wang R,Chen B

Sat Jul 01 00:00:00 EDT 2023

Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats.

Chinese journal of integrative medicine

Ge XF,Li SS,Liu YH,Lu MQ,Su HN,Yang X,Sun XW

Thu Jun 01 00:00:00 EDT 2023

Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages.

Free radical biology & medicine

Yu W,Chen C,Zhuang W,Wang W,Liu W,Zhao H,Lv J,Xie D,Wang Q,He F,Xu C,Chen B,Yamamoto T,Koyama H,Cheng J

Sat Jan 01 00:00:00 EST 2022

SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia.

Redox biology

Archer SL,Dasgupta A,Chen KH,Wu D,Baid K,Mamatis JE,Gonzalez V,Read A,Bentley RE,Martin AY,Mewburn JD,Dunham-Snary KJ,Evans GA,Levy G,Jones O,Al-Qazazi R,Ring B,Alizadeh E,Hindmarch CC,Rossi J,Lima PD,Falzarano D,Banerjee A,Colpitts CC

Thu Dec 01 00:00:00 EST 2022

Cadmium exposure induces pyroptosis in testicular tissue by increasing oxidative stress and activating the AIM2 inflammasome pathway.

The Science of the total environment

Zhou J,Zeng L,Zhang Y,Wang M,Li Y,Jia Y,Wu L,Su P

Tue Nov 15 00:00:00 EST 2022

Mesenchymal stem cells improve redox homeostasis and mitochondrial respiration in fibroblast cell lines with pathogenic MT-ND3 and MT-ND6 variants.

Stem cell research & therapy

Navaratnarajah T,Bellmann M,Seibt A,Anand R,Degistirici Ö,Meisel R,Mayatepek E,Reichert A,Baertling F,Distelmaier F

Fri Jun 17 00:00:00 EDT 2022

HO-1 Contributes to Luteolin-Triggered Ferroptosis in Clear Cell Renal Cell Carcinoma via Increasing the Labile Iron Pool and Promoting Lipid Peroxidation.

Oxidative medicine and cellular longevity

Han S,Lin F,Qi Y,Liu C,Zhou L,Xia Y,Chen K,Xing J,Liu Z,Yu W,Zhang Y,Zhou X,Rao T,Cheng F

Mon Jun 06 00:00:00 EDT 2022

Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy.

Stem cell research & therapy

Wang Y,Zhang Y,Chen K,Liu J,Wu D,Cheng Y,Wang H,Li Y

Sat Aug 13 00:00:00 EDT 2022

Icaritin alleviates docetaxel-induced skin injury by suppressing reactive oxygen species via estrogen receptors.

Thoracic cancer

Zou J,Xu MX,Li F,Wang YH,Li XQ,Yu DJ,Ma YJ,Zhang YY,Sun XD

Sat Jan 01 00:00:00 EST 2022

Wogonin alleviates liver injury in sepsis through Nrf2-mediated NF-κB signalling suppression.

Journal of cellular and molecular medicine

Dai JM,Guo WN,Tan YZ,Niu KW,Zhang JJ,Liu CL,Yang XM,Tao KS,Chen ZN,Dai JY

Tue Jun 01 00:00:00 EDT 2021

Wogonin alleviates liver injury in sepsis through Nrf2-mediated NF-κB signalling suppression.

Journal of cellular and molecular medicine

Dai JM,Guo WN,Tan YZ,Niu KW,Zhang JJ,Liu CL,Yang XM,Tao KS,Chen ZN,Dai JY

Tue Jun 01 00:00:00 EDT 2021

Indispensable role of mitochondria in maintaining the therapeutic potential of curcumin in acute kidney injury.

Journal of cellular and molecular medicine

Li L,Liu S,Zhou Y,Zhao M,Wang Y,Wang C,Lou P,Huang R,Ma L,Lu Y,Fu P,Liu J

Fri Oct 01 00:00:00 EDT 2021

Nrf2 Activation Is Involved in Cyclic Mechanical Stress-Stimulated Osteogenic Differentiation in Periodontal Ligament Stem Cells via PI3K/Akt Signaling and HO1-SOD2 Interaction.

Frontiers in cell and developmental biology

Xi X,Li Z,Liu H,Chen S,Liu D

Tue Jan 25 00:00:00 EST 2022

Synergistic Protective Effect of Konjac Mannan Oligosaccharides and Bacillus subtilis on Intestinal Epithelial Barrier Dysfunction in Caco-2 Cell Model and Mice Model of Lipopolysaccharide Stimulation.

Frontiers in immunology

Chen L,Zhang S,Wu S,Ren Z,Liu G,Wu J

Mon Dec 13 00:00:00 EST 2021

Resveratrol and its derivative pterostilbene ameliorate intestine injury in intrauterine growth-retarded weanling piglets by modulating redox status and gut microbiota.

Journal of animal science and biotechnology

Chen Y,Zhang H,Chen Y,Jia P,Ji S,Zhang Y,Wang T

Thu Jun 10 00:00:00 EDT 2021

PPARγ/SOD2 Protects Against Mitochondrial ROS-Dependent Apoptosis via Inhibiting ATG4D-Mediated Mitophagy to Promote Pancreatic Cancer Proliferation.

Frontiers in cell and developmental biology

Nie S,Shi Z,Shi M,Li H,Qian X,Peng C,Ding X,Zhang S,Lv Y,Wang L,Kong B,Zou X,Shen S

Wed Feb 23 00:00:00 EST 2022

CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes.

Molecular medicine reports

Jiang H,Niu F,Zheng Y,Xu Y

Thu Apr 01 00:00:00 EDT 2021

Diverging targets mediate the pathological roleof miR-199a-5p and miR-199a-3p by promoting cardiac hypertrophy and fibrosis.

Molecular therapy. Nucleic acids

Zeng N,Huang YQ,Yan YM,Hu ZQ,Zhang Z,Feng JX,Guo JS,Zhu JN,Fu YH,Wang XP,Zhang MZ,Duan JZ,Zheng XL,Xu JD,Shan ZX

Fri Dec 03 00:00:00 EST 2021

Comparison of the effects of resveratrol and its derivative pterostilbene on hepatic oxidative stress and mitochondrial dysfunction in piglets challenged with diquat.

Food & function

Zhang H,Chen Y,Chen Y,Jia P,Ji S,Xu J,Li Y,Wang T

Fri May 01 00:00:00 EDT 2020

Comparison of the protective effects of resveratrol and pterostilbene against intestinal damage and redox imbalance in weanling piglets.

Journal of animal science and biotechnology

Zhang H,Chen Y,Chen Y,Ji S,Jia P,Li Y,Wang T

Sat Nov 11 00:00:00 EST 2023

Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.

Haematologica

Maio N,Kim KS,Holmes-Hampton G,Singh A,Rouault TA

Sun Sep 01 00:00:00 EDT 2019

A cerium oxide loaded glycol chitosan nano-system for the treatment of dry eye disease.

Journal of controlled release : official journal of the Controlled Release Society

Yu F,Zheng M,Zhang AY,Han Z

Tue Dec 10 00:00:00 EST 2019

A cerium oxide loaded glycol chitosan nano-system for the treatment of dry eye disease.

Journal of controlled release : official journal of the Controlled Release Society

Yu F,Zheng M,Zhang AY,Han Z

Tue Dec 10 00:00:00 EST 2019

Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure.

Cell death & disease

Zhang J,An H,Ni K,Chen B,Li H,Li Y,Sheng G,Zhou C,Xie M,Chen S,Zhou T,Yang G,Chen X,Wu G,Jin S,Li M

Thu Apr 11 00:00:00 EDT 2019

Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure.

Cell death & disease

Zhang J,An H,Ni K,Chen B,Li H,Li Y,Sheng G,Zhou C,Xie M,Chen S,Zhou T,Yang G,Chen X,Wu G,Jin S,Li M

Thu Apr 11 00:00:00 EDT 2019

Clarithromycin synergizes with cisplatin to inhibit ovarian cancer growth in vitro and in vivo.

Journal of ovarian research

Zhou B,Xia M,Wang B,Thapa N,Gan L,Sun C,Guo E,Huang J,Lu Y,Cai H

Fri Nov 08 00:00:00 EST 2019

Exenatide Protects Against Cardiac Dysfunction by Attenuating Oxidative Stress in the Diabetic Mouse Heart.

Frontiers in endocrinology

Ding W,Chang WG,Guo XC,Liu Y,Xiao DD,Ding D,Wang JX,Zhang XJ

Tue Feb 25 00:00:00 EST 2020

Bioinformatics

Protein Aliases: indophenoloxidase B; IPO B; manganese SOD; manganese superoxide dismutase; manganese-containing superoxide dismutase; mangano-superoxide dismutase; mitochondrial superoxide dismutase 2; Mn superoxide dismutase; Superoxide dimutase 2, mitochondrial; superoxide dismutase; superoxide dismutase (Mn type); superoxide dismutase 2, mitochondrial; Superoxide dismutase [Mn], mitochondrial

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Gene Aliases: IPO-B; IPOB; Mn-SOD; MNSOD; MVCD6; Sod-2; SOD2

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UniProt ID: (Human) P04179, (Rat) P07895, (Mouse) P09671

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Entrez Gene ID: (Human) 6648, (Pig) 100154319, (Rat) 24787, (Mouse) 20656

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Function(s)

superoxide dismutase activity manganese ion binding identical protein binding DNA binding protein binding oxygen binding oxidoreductase activity metal ion binding oxidoreductase metabolite interconversion enzyme

Process(es)

response to reactive oxygen species response to superoxide age-dependent response to reactive oxygen species release of cytochrome c from mitochondria vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure regulation of transcription from RNA polymerase II promoter superoxide metabolic process regulation of blood pressure negative regulation of cell proliferation removal of superoxide radicals oxygen homeostasis negative regulation of neuron apoptotic process protein homotetramerization oxidation-reduction process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway age-dependent response to oxidative stress response to hypoxia liver development detection of oxygen glutathione metabolic process response to oxidative stress mitochondrion organization heart development aging sensory perception of sound locomotory behavior intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic mitochondrial changes response to radiation response to cold post-embryonic development response to manganese ion response to zinc ion response to selenium ion response to gamma radiation response to activity respiratory electron transport chain hemopoiesis response to nutrient levels response to lipopolysaccharide response to L-ascorbic acid response to silicon dioxide response to isolation stress response to immobilization stress vasodilation response to drug response to hydrogen peroxide superoxide anion generation hydrogen peroxide metabolic process negative regulation of apoptotic process positive regulation of nitric oxide biosynthetic process negative regulation of fat cell differentiation response to cadmium ion negative regulation of fibroblast proliferation neuron development response to axon injury erythrophore differentiation hydrogen peroxide biosynthetic process regulation of catalytic activity protein homooligomerization response to electrical stimulus regulation of mitochondrial membrane potential iron ion homeostasis response to hyperoxia response to magnetism cellular response to ethanol

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SOD2 Monoclonal Antibody (3A6C2)

SOD2 Antibody (66474-1-IG) in IHC (P)

Product Details

66474-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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