Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
66490-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
4B4H2
Immunogen
HRPT2; CDC73 Fusion Protein ag2959 (232-531 aa encoded by BC014351)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: WRTRTTILQ STGKNFSKNI FAILQSVKAR EEGRAPEQRP APNAAPVDPT LRTKQPIPAA YNRYDQERFK GKEETEGFKI DTMGTYHGMT LKSVTEGASA RKTQTPAAQP VPRPVSQARP PPNQKKGSRT PIIIIPAATT SLITMLNAKD LLQDLKFVPS DEKKKQGCQR ENETLIQRRK DQMQPGGTAI SVTVPYRVVD QPLKLMPQDW DRVVAVFVQG PAWQFKGWPW LLPDGSPVDI FAKIKAFHLK YDEVRLDPNV QKWDVTVLEL SYHKRHLDRP VFLRFWETLD RYMVKHKSHL RF (232-531 aa encoded by BC014351)
Target Information
Cdc73 is a tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. Cdc73 is part of the PAF1 complex, a five-subunit protein complex composed of Paf1, Cdc73, Leo1, Rtf1 and Ctr9. PAF1 was first purified from yeast in association with RNA polymerase II and is believed to function in transcription elongation. The yeast PAF (yPAF) complex interacts with RNA polymerase II and coordinates the setting of histone marks associated with active transcription. In addition to coordinating events during transcription (initiation, promoter clearance, and elongation), hPAF also coordinates events in RNA quality control. Cdc73 may also be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cell division cycle 73 Paf1/RNA polymerase II complex component-like protein; cell division cycle 73, Paf1/RNA polymerase II complex component, homolog; Cell division cycle protein 73 homolog; hyperparathyroidism 2 (with jaw tumor); hyperparathyroidism 2 homolog; Hyperparathyroidism 2 protein; Hyperparathyroidism 2 protein homolog; Paf1/RNA polymerase II complex component; Parafibromin; Vcell division cycle 73, Paf1/RNA polymerase II complex component, homolog
Gene Aliases: 8430414L16Rik; BC027756; C130030P16Rik; C1orf28; C81219; CDC73; FIHP; HPTJT; HRPT1; HRPT2; HYX
UniProt ID: (Human) Q6P1J9, (Mouse) Q8JZM7, (Rat) Q4V8C8
Entrez Gene ID: (Human) 79577, (Pig) 100526068, (Mouse) 214498, (Rat) 304832
negative regulation of transcription from RNA polymerase II promoter
endodermal cell fate commitment
transcription, DNA-templated
mRNA polyadenylation
cell cycle
negative regulation of cell proliferation
histone monoubiquitination
Wnt signaling pathway
stem cell population maintenance
positive regulation of Wnt signaling pathway
positive regulation of mRNA 3'-end processing
protein destabilization
positive regulation of transcription elongation from RNA polymerase II promoter
histone H2B ubiquitination
negative regulation of myeloid cell differentiation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of fibroblast proliferation
negative regulation of epithelial cell proliferation
cellular response to lipopolysaccharide
negative regulation of G1/S transition of mitotic cell cycle
transcription elongation from RNA polymerase II promoter
beta-catenin-TCF complex assembly
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support