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ARL13B Monoclonal Antibody (1H6C3)

ARL13B Antibody in Immunocytochemistry (ICC/IF)

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ARL13B Antibody (66739-1-IG) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed MDCK cells using 66739-1-Ig (ARL13B antibody) at dilution of 1:100 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Mouse IgG (H+L).

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Product Details

66739-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 3 publications 3 publications

Immunocytochemistry (ICC/IF)

1:50-1:500

View 12 publications 12 publications

Product Specifications

Species Reactivity

Dog, Human, Mouse, Pig

Published species

Not Applicable

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1H6C3

Immunogen

ARL13B Fusion Protein Ag12031 (1-321 aa encoded by BC094725)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MFSLMASCC GWFKRWREPV RLANKQDKEG ALGEADVIEC LSLEKLVNEH KCLCQIEPCS AISGYGKKID KSIKKGLYWL LHVIARDFDA LNERIQKETT EQRALEEQEK QERAERVRKL REERKQNEQE QAELDGTSGL AELDPEPTNP FQPIASVIIE NEGKLEREKK NQKMEKDSDG CHLKHKMEHE QIETQGQVNH NGQKNNEFGL VENYKEALTQ QLKNEDETDR PSLESANGKK KTKKLRMKRN HRVEPLNIDD CAPESPTPPP PPPPVGWGTP KVTRLPKLEP LGETHHNDFY RKPLPPLAVP QRPNSDAHDV IS (1-321 aa encoded by BC094725)

Target Information

This gene encodes a member of the ADP-ribosylation factor-like family. The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. This protein is localized in the cilia and plays a role in cilia formation and in maintenance of cilia. Mutations in this gene are the cause of Joubert syndrome 8. Alternate splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Regulation of Primary Cilium Length by O-GlcNAc during Neuronal Development in a Human Neuron Model.

Cells

Tian JL,Huang CW,Eslami F,Mannino MP,Mai RL,Hart GW

Wed May 31 00:00:00 EDT 2023

XBP1 Activation Reduces Severity of Polycystic Kidney Disease due to a Nontruncating Polycystin-1 Mutation in Mice.

Journal of the American Society of Nephrology : JASN

Krappitz M,Bhardwaj R,Dong K,Staudner T,Yilmaz DE,Pioppini C,Westergerling P,Ruemmele D,Hollmann T,Nguyen TA,Cai Y,Gallagher AR,Somlo S,Fedeles S

Sun Jan 01 00:00:00 EST 2023

Disease-associated mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2.

Journal of cell science

Shak C,Vuolo L,Uddin B,Katoh Y,Brown T,Mukhopadhyay AG,Heesom K,Roberts AJ,Stevenson N,Nakayama K,Stephens DJ

Wed Mar 01 00:00:00 EST 2023

Disease-associated mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2.

Journal of cell science

Shak C,Vuolo L,Uddin B,Katoh Y,Brown T,Mukhopadhyay AG,Heesom K,Roberts AJ,Stevenson N,Nakayama K,Stephens DJ

Wed Mar 01 00:00:00 EST 2023

Stromal cells of giant cell tumor of bone show primary cilia in giant cell tumor of bone.

Microscopy research and technique

Castiella T,Iruzubieta P,Monleón E,Cardiel MJ,Gómez-Vallejo J,Monzón M,Junquera MC

Tue Mar 01 00:00:00 EST 2022

INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex.

Nature communications

Mascibroda LG,Shboul M,Elrod ND,Colleaux L,Hamamy H,Huang KL,Peart N,Singh MK,Lee H,Merriman B,Jodoin JN,Sitaram P,Lee LA,Fathalla R,Al-Rawashdeh B,Ababneh O,El-Khateeb M,Escande-Beillard N,Nelson SF,Wu Y,Tong L,Kenney LJ,Roy S,Russell WK,Amiel J,Reversade B,Wagner EJ

Thu Oct 13 00:00:00 EDT 2022

INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex.

Nature communications

Thu Oct 13 00:00:00 EDT 2022

The Male Mouse Meiotic Cilium Emanates from the Mother Centriole at Zygotene Prior to Centrosome Duplication.

Cells

López-Jiménez P,Pérez-Martín S,Hidalgo I,García-Gonzalo FR,Page J,Gómez R

Thu Dec 29 00:00:00 EST 2022

Multiple ciliary localization signals control INPP5E ciliary targeting.

eLife

Cilleros-Rodriguez D,Martin-Morales R,Barbeito P,Deb Roy A,Loukil A,Sierra-Rodero B,Herranz G,Pampliega O,Redrejo-Rodriguez M,Goetz SC,Izquierdo M,Inoue T,Garcia-Gonzalo FR

Mon Sep 05 00:00:00 EDT 2022

CCP1, a Tubulin Deglutamylase, Increases Survival of Rodent Spinal Cord Neurons following Glutamate-Induced Excitotoxicity.

eNeuro

Ramadan YH,Gu A,Ross N,McEwan SA,Barr MM,Firestein BL,O'Hagan R

Fri Jun 18 00:00:00 EDT 2021

HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.

Life science alliance

Barbeito P,Tachibana Y,Martin-Morales R,Moreno P,Mykytyn K,Kobayashi T,Garcia-Gonzalo FR

Mon Mar 01 00:00:00 EST 2021

The autophagy protein ATG16L1 cooperates with IFT20 and INPP5E to regulate the turnover of phosphoinositides at the primary cilium.

Cell reports

Boukhalfa A,Roccio F,Dupont N,Codogno P,Morel E

Tue Apr 27 00:00:00 EDT 2021

Embryonic and foetal expression patterns of the ciliopathy gene CEP164.

PloS one

Devlin LA,Ramsbottom SA,Overman LM,Lisgo SN,Clowry G,Molinari E,Powell L,Miles CG,Sayer JA

Wed Apr 01 00:00:00 EDT 2020

Use of patient derived urine renal epithelial cells to confirm pathogenicity of PKHD1 alleles.

BMC nephrology

Molinari E,Srivastava S,Dewhurst RM,Sayer JA

Thu Oct 15 00:00:00 EDT 2020

Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts.

Scientific reports

Molinari E,Ramsbottom SA,Srivastava S,Booth P,Alkanderi S,McLafferty SM,Devlin LA,White K,Gunay-Aygun M,Miles CG,Sayer JA

Thu Jul 25 00:00:00 EDT 2019

Bioinformatics

Protein Aliases: ADP-ribosylation factor like GTPase 13B; ADP-ribosylation factor-like 13B; ADP-ribosylation factor-like 2-like 1; ADP-ribosylation factor-like protein 13B; ADP-ribosylation factor-like protein 2-like 1; ARL2-like protein 1; Protein hennin

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Gene Aliases: A530097K21Rik; A930014M17Rik; ARL13B; ARL2L1; C530009C10Rik; hnn; JBTS8

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UniProt ID: (Human) Q3SXY8, (Mouse) Q640N2

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Entrez Gene ID: (Dog) 487934, (Pig) 100624385, (Human) 200894, (Mouse) 68146

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Function(s)

protein binding GTP binding nucleotide binding

Process(es)

heart looping smoothened signaling pathway small GTPase mediated signal transduction dorsal/ventral pattern formation neural tube patterning interneuron migration from the subpallium to the cortex formation of radial glial scaffolds nonmotile primary cilium assembly cilium assembly left/right axis specification multicellular organism development determination of left/right symmetry

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ARL13B Monoclonal Antibody (1H6C3)

ARL13B Antibody (66739-1-IG) in ICC/IF

Product Details

66739-1-IG

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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