Proteintech

Collagen Type I Monoclonal Antibody (1E9A7)

Collagen Type I Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

Collagen Type I Antibody (67288-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 67288-1-Ig (Collagen Type I antibody) at dilution of 1:5000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Collagen Type I Antibody in Western Blot (WB)

Product Image Gallery

Product Details

67288-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:10,000

View 84 publications 84 publications

Immunohistochemistry (IHC)

View 23 publications 23 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:5,000

Immunocytochemistry (ICC/IF)

View 16 publications 16 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Pig

Published species

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1E9A7

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

500 µg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. Collagen I is a member of group I collagen (fibril-forming collagen) found in most connective tissues, and is abundant in bone, cornea, dermis and tendon. Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in the COL1A2 gene which codes for the alpha-2 chain, however, tend to be less severe than mutations in the COL1A1 gene, reflecting the different role of alpha-2 chains in matrix integrity. Reciprocal translocations between chromosomes 17 and 22, where Collagen Type 1 genes and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Tue Nov 01 00:00:00 EDT 2022

Patient-derived microphysiological model identifies the therapeutic potential of metformin for thoracic aortic aneurysm.

EBioMedicine

Ma W,Zhang J,Liu S,Yan S,Xu K,Zhang YS,Abudupataer M,Ming Y,Zhu S,Xiang B,Zhou X,Luo S,Huang H,Tang Y,Zhang S,Xie Z,Chen N,Sun X,Li J,Lai H,Wang C,Zhu K,Zhang W

Fri Jul 01 00:00:00 EDT 2022

Investigation of the Therapeutic Effect of Total Alkaloids of Corydalis saxicola Bunting on CCl₄-Induced Liver Fibrosis in Rats by LC/MS-Based Metabolomics Analysis and Network Pharmacology.

Metabolites

Wang Q,Luo Z,Li D,Qin J,Pan Z,Guo B,Deng L,Nong Y,Huang Z,He Y,Guo H,Zhu D,Liang Y,Su Z

Wed Dec 21 00:00:00 EST 2022

Hypoxia-Induced Scleral HIF-2α Upregulation Contributes to Rises in MMP-2 Expression and Myopia Development in Mice.

Investigative ophthalmology & visual science

Wu W,Su Y,Hu C,Tao H,Jiang Y,Zhu G,Zhu J,Zhai Y,Qu J,Zhou X,Zhao F

Fri Jul 08 00:00:00 EDT 2022

Masquelet technique: Effects of vancomycin concentration on quality of the induced membrane.

Injury

Xie J,Wang W,Fan X,Li H,Wang H,Liao R,Hu Y,Zeng M

Tue Mar 01 00:00:00 EST 2022

Intracellular hydroxyproline imprinting following resolution of bleomycin-induced pulmonary fibrosis.

The European respiratory journal

Song S,Fu Z,Guan R,Zhao J,Yang P,Li Y,Yin H,Lai Y,Gong G,Zhao S,Yu J,Peng X,He Y,Luo Y,Zhong N,Su J

Sun May 01 00:00:00 EDT 2022

Kaposi's sarcoma-associated herpesvirus vFLIP promotes MEndT to generate hybrid M/E state for tumorigenesis.

PLoS pathogens

Chen W,Ding Y,Liu D,Lu Z,Wang Y,Yuan Y

Wed Dec 01 00:00:00 EST 2021

Dickkopf 3: a Novel Target Gene of miR-25-3p in Promoting Fibrosis-Related Gene Expression in Myocardial Fibrosis.

Journal of cardiovascular translational research

Zeng N,Wen YH,Pan R,Yang J,Yan YM,Zhao AZ,Zhu JN,Fang XH,Shan ZX

Wed Dec 01 00:00:00 EST 2021

Costunolide Loaded in pH-Responsive Mesoporous Silica Nanoparticles for Increased Stability and an Enhanced Anti-Fibrotic Effect.

Pharmaceuticals (Basel, Switzerland)

Niu X,Wang X,Niu B,Meng Y,He H,Wang Y,Li G

Thu Sep 23 00:00:00 EDT 2021

Nicotinamide mononucleotide attenuates isoproterenol-induced cardiac fibrosis by regulating oxidative stress and Smad3 acetylation.

Life sciences

Wu K,Li B,Lin Q,Xu W,Zuo W,Li J,Liu N,Tu T,Zhang B,Xiao Y,Liu Q

Tue Jun 01 00:00:00 EDT 2021

DNMT1-Induced miR-152-3p Suppression Facilitates Cardiac Fibroblast Activation in Cardiac Fibrosis.

Cardiovascular toxicology

Xu SS,Ding JF,Shi P,Shi KH,Tao H

Wed Dec 01 00:00:00 EST 2021

DNMT1-Induced miR-152-3p Suppression Facilitates Cardiac Fibroblast Activation in Cardiac Fibrosis.

Cardiovascular toxicology

Xu SS,Ding JF,Shi P,Shi KH,Tao H

Wed Dec 01 00:00:00 EST 2021

Chinese Herbal Medicine Suyin Detoxification Granule Inhibits Pyroptosis and Epithelial-Mesenchymal Transition by Downregulating MAVS/NLRP3 to Alleviate Renal Injury.

Journal of inflammation research

Zhu Y,Huang G,Yang Y,Yong C,Yu X,Wang G,Yi L,Gao K,Tian F,Qian S,Zhou E,Zou Y

Fri Apr 29 00:00:00 EDT 2022

Chinese Herbal Medicine Suyin Detoxification Granule Inhibits Pyroptosis and Epithelial-Mesenchymal Transition by Downregulating MAVS/NLRP3 to Alleviate Renal Injury.

Journal of inflammation research

Zhu Y,Huang G,Yang Y,Yong C,Yu X,Wang G,Yi L,Gao K,Tian F,Qian S,Zhou E,Zou Y

Fri Apr 29 00:00:00 EDT 2022

Chinese Herbal Medicine Suyin Detoxification Granule Inhibits Pyroptosis and Epithelial-Mesenchymal Transition by Downregulating MAVS/NLRP3 to Alleviate Renal Injury.

Journal of inflammation research

Zhu Y,Huang G,Yang Y,Yong C,Yu X,Wang G,Yi L,Gao K,Tian F,Qian S,Zhou E,Zou Y

Fri Apr 29 00:00:00 EDT 2022

Chinese Herbal Medicine Suyin Detoxification Granule Inhibits Pyroptosis and Epithelial-Mesenchymal Transition by Downregulating MAVS/NLRP3 to Alleviate Renal Injury.

Journal of inflammation research

Zhu Y,Huang G,Yang Y,Yong C,Yu X,Wang G,Yi L,Gao K,Tian F,Qian S,Zhou E,Zou Y

Fri Apr 29 00:00:00 EDT 2022

Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis.

Food & function

Zheng S,Cao P,Yin Z,Wang X,Chen Y,Yu M,Xu B,Liao C,Duan Y,Zhang S,Han J,Yang X

Mon Mar 15 00:00:00 EDT 2021

Macrophage exosomes transfer angiotensin II type 1 receptor to lung fibroblasts mediating bleomycin-induced pulmonary fibrosis.

Chinese medical journal

Sun NN,Zhang Y,Huang WH,Zheng BJ,Jin SY,Li X,Meng Y

Thu Sep 02 00:00:00 EDT 2021

Bone marrow-derived mesenchymal stem cells attenuate silica-induced pulmonary fibrosis by inhibiting apoptosis and pyroptosis but not autophagy in rats.

Ecotoxicology and environmental safety

Zhao Q,Hao C,Wei J,Huang R,Li C,Yao W

Sat Apr 10 00:00:00 EDT 2021

Quercetin prevents isoprenaline-induced myocardial fibrosis by promoting autophagy via regulating miR-223-3p/FOXO3.

Cell cycle (Georgetown, Tex.)

Hu J,Wang X,Cui X,Kuang W,Li D,Wang J

Thu Jul 01 00:00:00 EDT 2021

Weighted correlation network analysis identifies FN1, COL1A1 and SERPINE1 associated with the progression and prognosis of gastric cancer.

Cancer biomarkers : section A of Disease markers

Zhao Q,Xie J,Xie J,Zhao R,Song C,Wang H,Rong J,Yan L,Song Y,Wang F,Xie Y

Tue Dec 21 00:00:00 EST 2021

Heat shock protein 90 inhibitor ameliorates pancreatic fibrosis by degradation of transforming growth factor-β receptor.

Cellular signalling

Peng YF,Lin H,Liu DC,Zhu XY,Huang N,Wei YX,Li L

Sun Aug 01 00:00:00 EDT 2021

Anti-Fibrosis Effects of Magnesium Lithospermate B in Experimental Pulmonary Fibrosis: By Inhibiting TGF-βRI/Smad Signaling.

Molecules (Basel, Switzerland)

Luo X,Deng Q,Xue Y,Zhang T,Wu Z,Peng H,Xuan L,Pan G

Fri Mar 19 00:00:00 EDT 2021

Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma.

Cancer cell international

Yin W,Zhu H,Tan J,Xin Z,Zhou Q,Cao Y,Wu Z,Wang L,Zhao M,Jiang X,Ren C,Tang G

Tue May 25 00:00:00 EDT 2021

Diverging targets mediate the pathological roleof miR-199a-5p and miR-199a-3p by promoting cardiac hypertrophy and fibrosis.

Molecular therapy. Nucleic acids

Zeng N,Huang YQ,Yan YM,Hu ZQ,Zhang Z,Feng JX,Guo JS,Zhu JN,Fu YH,Wang XP,Zhang MZ,Duan JZ,Zheng XL,Xu JD,Shan ZX

Fri Dec 03 00:00:00 EST 2021

Radiation‑induced dysfunction of energy metabolism in the heart results in the fibrosis of cardiac tissues.

Molecular medicine reports

Xu P,Yi Y,Luo Y,Liu Z,Xu Y,Cai J,Zeng Z,Liu A

Wed Dec 01 00:00:00 EST 2021

Radiation‑induced dysfunction of energy metabolism in the heart results in the fibrosis of cardiac tissues.

Molecular medicine reports

Xu P,Yi Y,Luo Y,Liu Z,Xu Y,Cai J,Zeng Z,Liu A

Wed Dec 01 00:00:00 EST 2021

Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.

Molecular medicine reports

Huang H,Liu K,Ou H,Qian X,Wan J

Tue Jun 01 00:00:00 EDT 2021

Ppic modulates CCl₄-induced liver fibrosis and TGF-β-caused mouse hepatic stellate cell activation and regulated by miR-137-3p.

Toxicology letters

Yang X,Shu B,Zhou Y,Li Z,He C

Sun Oct 10 00:00:00 EDT 2021

Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis.

Nature cell biology

Kobayashi Y,Tata A,Konkimalla A,Katsura H,Lee RF,Ou J,Banovich NE,Kropski JA,Tata PR

Sat Aug 01 00:00:00 EDT 2020

Expression of collagen type 1 alpha 1 indicates lymph node metastasis and poor outcomes in squamous cell carcinomas of the lung.

PeerJ

Dong S,Zhu P,Zhang S

Sun Apr 17 00:00:00 EDT 2022

Low-magnitude vibration induces osteogenic differentiation of bone marrow mesenchymal stem cells via miR-378a-3p/Grb2 pathway to promote bone formation in a rat model of age-related bone loss.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Yu X,Zeng Y,Bao M,Wen J,Zhu G,Cao C,He X,Li L

Tue Sep 01 00:00:00 EDT 2020

Androgen aggravates liver fibrosis by activation of NLRP3 inflammasome in CCl₄-induced liver injury mouse model.

American journal of physiology. Endocrinology and metabolism

Ma X,Zhou Y,Qiao B,Jiang S,Shen Q,Han Y,Liu A,Chen X,Wei L,Zhou L,Zhao J

Fri May 01 00:00:00 EDT 2020

Androgen aggravates liver fibrosis by activation of NLRP3 inflammasome in CCl₄-induced liver injury mouse model.

American journal of physiology. Endocrinology and metabolism

Ma X,Zhou Y,Qiao B,Jiang S,Shen Q,Han Y,Liu A,Chen X,Wei L,Zhou L,Zhao J

Fri May 01 00:00:00 EDT 2020

Sustained delivery of PlGF-2_123-144*-fused BMP2-related peptide P28 from small intestinal submucosa/polylactic acid scaffold material for bone tissue regeneration.

RSC advances

Xiong Z,Cui W,Sun T,Teng Y,Qu Y,Yang L,Zhou J,Chen K,Yao S,Shao Z,Guo X

Thu Feb 13 00:00:00 EST 2020

Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and apoptosis.

Therapeutic advances in chronic disease

Miao K,Pan T,Mou Y,Zhang L,Xiong W,Xu Y,Yu J,Wang Y

Sat Apr 16 00:00:00 EDT 2022

Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and apoptosis.

Therapeutic advances in chronic disease

Miao K,Pan T,Mou Y,Zhang L,Xiong W,Xu Y,Yu J,Wang Y

Sat Apr 16 00:00:00 EDT 2022

Novel role of the clustered miR-23b-3p and miR-27b-3p in enhanced expression of fibrosis-associated genes by targeting TGFBR3 in atrial fibroblasts.

Journal of cellular and molecular medicine

Yang Z,Xiao Z,Guo H,Fang X,Liang J,Zhu J,Yang J,Li H,Pan R,Yuan S,Dong W,Zheng XL,Wu S,Shan Z

Wed May 01 00:00:00 EDT 2019

The effect of different hydroxyapatite microparticles on the osteogenic differentiation of MC3T3-E1 preosteoblasts.

Journal of materials chemistry. B

Xu W,Xu C,Yi J,Dai H

Tue Aug 28 00:00:00 EDT 2018

Involvement of Smad3 pathway in atrial fibrosis induced by elevated hydrostatic pressure.

Journal of cellular physiology

Wei W,Rao F,Liu F,Xue Y,Deng C,Wang Z,Zhu J,Yang H,Li X,Zhang M,Fu Y,Zhu W,Shan Z,Wu S

Fri Jun 01 00:00:00 EDT 2018

LncRNA-ATB/microRNA-200a/β-catenin regulatory axis involved in the progression of HCV-related hepatic fibrosis.

Gene

Fu N,Zhao SX,Kong LB,Du JH,Ren WG,Han F,Zhang QS,Li WC,Cui P,Wang RQ,Zhang YG,Nan YM

Fri Jun 30 00:00:00 EDT 2017

Angiotensin(1-7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1β/Smad circuit.

Free radical biology & medicine

Zhang LL,Huang S,Ma XX,Zhang WY,Wang D,Jin SY,Zhang YP,Li Y,Li X

Mon Aug 01 00:00:00 EDT 2016

Crucial Role of miR-433 in Regulating Cardiac Fibrosis.

Theranostics

Tao L,Bei Y,Chen P,Lei Z,Fu S,Zhang H,Xu J,Che L,Chen X,Sluijter JP,Das S,Cretoiu D,Xu B,Zhong J,Xiao J,Li X

Mon Oct 16 00:00:00 EDT 2017

MicroRNA-130a and -130b enhance activation of hepatic stellate cells by suppressing PPARγ expression: A rat fibrosis model study.

Biochemical and biophysical research communications

Lu L,Wang J,Lu H,Zhang G,Liu Y,Wang J,Zhang Y,Shang H,Ji H,Chen X,Duan Y,Li Y

Fri Sep 25 00:00:00 EDT 2015

Bioinformatics

Protein Aliases: alpha 2 type I procollagen; alpha 2(I) procollagen; alpha 2(I)-collagen; Alpha-1 type I collagen; Alpha-2 type I collagen; alpha1 chain of type I collagen; alpha1(I) procollagen; alpha2 chain of type I collagen; COL1; COL1A1; COL1A1; matrix protein; collagen alpha 1 chain type I; Collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; Collagen alpha-2(I) chain; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-1 chain; collagen of skin, tendon and bone, alpha-2 chain; collagen type I alpha 1; collagen, type I, alpha 1; collagen, type I, alpha 2; pro-alpha-1 collagen type 1; Type I Collagen; type I proalpha 1; type I procollagen; type I procollagen alpha 1 chain

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Gene Aliases: COL1A1; COL1A2; EDSC; OI1; OI2; OI3; OI4

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UniProt ID: (Human) P02452, (Human) P08123

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Entrez Gene ID: (Pig) 100738123, (Human) 1277, (Human) 1278, (Pig) 100626716

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Function(s)

extracellular matrix structural constituent protein binding identical protein binding metal ion binding platelet-derived growth factor binding protein binding, bridging SMAD binding extracellular matrix structural protein

Process(es)

Performance Guarantee

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Collagen Type I Monoclonal Antibody (1E9A7)

Collagen Type I Antibody (67288-1-IG) in IHC (P)

Product Details

67288-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

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Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

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Contains

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