Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
67733-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2D8H1
Immunogen
METTL3 Fusion Protein Ag7110
Conjugate
Form
Liquid
Concentration
398 µg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
METTL3 is the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase; hMETTL3; m6a methyltransferase; methyltransferase-like 3; Methyltransferase-like protein 3; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; mRNA m(6)A methyltransferase; MT-A70; N6-adenosine-methyltransferase 70 kDa subunit; N6-adenosine-methyltransferase catalytic subunit; N6-adenosine-methyltransferase subunit METTL3
Gene Aliases: 2310024F18Rik; IME4; M6A; METTL3; MT-A70; MTA70; Spo8
UniProt ID: (Human) Q86U44, (Mouse) Q8C3P7
Entrez Gene ID: (Human) 56339, (Mouse) 56335
mRNA binding
RNA methyltransferase activity
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
protein heterodimerization activity
S-adenosyl-L-methionine binding
mRNA (N6-adenosine)-methyltransferase activity
RNA binding
protein binding
methyltransferase activity
transferase activity
RNA metabolism protein
RNA methyltransferase
nucleic acid metabolism protein
mRNA splicing, via spliceosome
RNA methylation
adenosine to inosine editing
mRNA processing
circadian rhythm
gene expression
stem cell population maintenance
primary miRNA processing
mRNA destabilization
mRNA methylation
positive regulation of cap-independent translational initiation
primary miRNA methylation
nucleobase-containing compound metabolic process
mRNA modification
methylation
rhythmic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support