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Product Details
67830-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4B12G2
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
The protein encoded by BAD is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BAD; bcl-2 associated death agonist; Bcl-2-binding component 6; Bcl-2-like protein 8; BCL-X/BCL-2 binding protein; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death; Bcl2-antagonist of cell death; BCL2-antagonist of cell death protein; BCL2-associated agonist of cell death; bcl2-associated death promoter; BCL2-binding component 6; BCL2-binding protein; Bcl2-L-8; OTTMUSP00000017561; OTTMUSP00000022400
Gene Aliases: AI325008; BAD; BBC2; BBC6; BCL2L8
UniProt ID: (Human) Q92934, (Mouse) Q61337, (Rat) O35147
Entrez Gene ID: (Human) 572, (Mouse) 12015, (Rat) 64639
release of cytochrome c from mitochondria
glucose catabolic process
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell proliferation
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of mitochondrial membrane potential
suppression by virus of host apoptotic process
cytokine-mediated signaling pathway
positive regulation of insulin secretion
positive regulation of glucokinase activity
positive regulation of insulin secretion involved in cellular response to glucose stimulus
glucose homeostasis
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity involved in apoptotic process
type B pancreatic cell proliferation
positive regulation of B cell differentiation
positive regulation of T cell differentiation
positive regulation of proteolysis
negative regulation of cytolysis
ADP metabolic process
ATP metabolic process
regulation of mitochondrial membrane permeability
pore complex assembly
positive regulation of epithelial cell proliferation
positive regulation of apoptotic process by virus
cellular process regulating host cell cycle in response to virus
cellular response to organic substance
cellular response to nicotine
positive regulation of release of cytochrome c from mitochondria
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
intrinsic apoptotic signaling pathway
activation of cysteine-type endopeptidase activity
positive regulation of neuron death
positive regulation of type B pancreatic cell development
response to hypoxia
response to hormone
response to glucose
response to organic substance
response to organic cyclic compound
response to estradiol
response to progesterone
response to testosterone
response to oleic acid
response to drug
response to hydrogen peroxide
response to amino acid
response to ethanol
response to glucocorticoid
response to calcium ion
cellular response to chromate
cellular response to mechanical stimulus
cellular response to lipid
cellular response to hypoxia
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
spermatogenesis
positive regulation of autophagy
cerebral cortex development
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
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