Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Neurogenin 2 Recombinant Superclonal Antibody (15HCLC)
Advanced Verification
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 3
Neurogenin 2 Antibody (711595) in ICC/IF
For immunofluorescence analysis, retinoic acid (10 uM, 5 days) treated SHSY-5Y cells were fixed and permeabilized for detection of endogenous Neurogenin-2 using Anti-Neurogenin-2 Recombinant Rabbit Polyclonal Antibody (Product # 711595, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representa... View More
Product Details
711595
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Superclonal
Type
Antibody
Clone
15HCLC
Immunogen
Protein corresponding to Human NEUROG2 (1-272)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2633189
Product Specific Information
This antibody is predicted to react with Monkey, Dog, Bovine and Rabbit
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
Target Information
Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis from migratory neural crest cells. In the course of mouse neurogenesis, Ngn2 and Ngn1 are expressed in distinct progenitor populations residing in the central and peripheral nervous systems. Mutation analyses demonstrate that Ngn1 is required for the determination of neuronal precursors for proximal cranial sensory ganglia and that Ngn2 is necessary for the determination of precursors for epibranchial placode-derived sensory neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: atonal homolog 4; bHLHa8; Class A basic helix-loop-helix protein 8; Helix-loop-helix protein mATH-4A; mATH4A; Neurogenin-2; neurogenin2; NGN-2; Protein atonal homolog 4
Gene Aliases: Ath4a; ATOH4; BHLHA8; Math4A; NEUROG2; ngn-2; NGN2
UniProt ID: (Human) Q9H2A3, (Mouse) P70447
Entrez Gene ID: (Human) 63973, (Mouse) 11924
transcription, DNA-templated
neuron differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
neuron migration
regulation of transcription, DNA-templated
multicellular organism development
nervous system development
axon guidance
central nervous system neuron development
neurogenesis
cell differentiation
forebrain development
cell fate commitment
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
cell maturation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support