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Sequence of this protein is as follows: SPEFVLKEAQ EGCEPQAFAE LASEGEGPGP ETRLSTSLSG LNEKNPYRDS AYFSDLEAEA EATSGPEKKC GGDRAPGPEL GLRSTGQPSE QVCLRPGVSG
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AATYK; Apoptosis-associated tyrosine kinase; apoptosis-associated tyrosine kinase 1B; Brain apoptosis-associated tyrosine kinase; CDK5-binding protein; Lemur tyrosine kinase 1; p35-binding protein; p35BP; protein phosphatase 1, regulatory subunit 77; Serine/threonine-protein kinase LMTK1
Gene Aliases: AATK; AATYK; AATYK1; KIAA0641; LMR1; LMTK1; mKIAA0641; p35BP; PPP1R77
UniProt ID: (Human) Q6ZMQ8, (Mouse) Q80YE4
Entrez Gene ID: (Human) 9625, (Mouse) 11302
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