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Invitrogen
ABCA1 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 4
ABCA1 Antibody (PA5-69245) in WB
Western blot was performed using anti-ABCA1 Polyclonal Antibody (Product # PA5-69245) and a 254 kDa band corresponding to ABCA1 was increased upon THP-1 differentiated to macrophages and LPS treatment in THP-1. Also, the expression was observed to be high in Mouse and Rat Liver when compared to other tissues. Membrane enriched extracts (30 µg lysate) of THP-1 (Lane 1), THP-1 differentiated to macrophages (Lane 2), THP-1 treated with LPS (1 µg/mL for 24hrs) (Lane 3), Mouse Liver (Lane 4), Rat Liver (Lane 5), Mouse Brown Adipose (Lane 6) and... View More
Product Details
PA5-69245
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide corresponding to a region of mouse ABCA1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2688866
Product Specific Information
This target displays homology in the following species: Cow: 93%; Dog: 86%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 86%
Target Information
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC 1; ABC 1 antibody; ABC Transporter 1; ABC-1; ABC1 antibody; ATP-binding cassette 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; CERP antibody; Phospholipid-transporting ATPase ABCA1
Gene Aliases: ABC-1; Abc1; Abca1
UniProt ID: (Mouse) P41233
Entrez Gene ID: (Mouse) 11303
nucleotide binding
receptor binding
transporter activity
protein binding
ATP binding
phospholipid transporter activity
anion transmembrane transporter activity
ATPase activity
cholesterol transporter activity
syntaxin binding
small GTPase binding
apolipoprotein binding
apolipoprotein A-I binding
apolipoprotein A-I receptor activity
ATPase activity, coupled to transmembrane movement of substances
ATPase binding
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
peptide secretion
protein lipidation
transport
phagocytosis, engulfment
lysosome organization
G-protein coupled receptor signaling pathway
cholesterol metabolic process
positive regulation of cholesterol efflux
phospholipid transport
endosomal transport
cholesterol transport
positive regulation of cAMP biosynthetic process
intracellular cholesterol transport
regulation of Cdc42 protein signal transduction
cholesterol efflux
phospholipid efflux
high-density lipoprotein particle assembly
apolipoprotein A-I-mediated signaling pathway
lipoprotein metabolic process
lipoprotein biosynthetic process
cholesterol homeostasis
reverse cholesterol transport
phospholipid translocation
interleukin-1 beta secretion
transmembrane transport
phospholipid homeostasis
response to high density lipoprotein particle
platelet dense granule organization
cellular response to lipopolysaccharide
cellular response to retinoic acid
anion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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