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Product Details
PA5-103634
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ABCA7(Accession Q8IZY2), corresponding to amino acid residues L739-P789.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2852968
Product Specific Information
Antibody detects endogenous levels of total ABCA7.
Target Information
ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC 1 antibody; ABC Transporter 1; ABC1; ABC1 antibody; ABCA-SSN; ATP-binding cassette sub-family A member 7; ATP-binding cassette, sub-family A (ABC1), member 7; Autoantigen SS-N; CERP; CERP antibody; EC 2.2.1.1; EC 3.6.3; EC 3.6.3.41; FLJ40025; Macrophage ABC transporter; Phospholipid-transporting ATPase ABCA7
Gene Aliases: ABCA-SSN; ABCA7; ABCX; AD9
UniProt ID: (Human) Q8IZY2
Entrez Gene ID: (Human) 10347
phagocytosis
memory
positive regulation of cholesterol efflux
phospholipid scrambling
peptide cross-linking
negative regulation of ATPase activity
positive regulation of ATPase activity
cholesterol efflux
phospholipid efflux
high-density lipoprotein particle assembly
protein localization to nucleus
apolipoprotein A-I-mediated signaling pathway
negative regulation of amyloid precursor protein biosynthetic process
positive regulation of phagocytosis
transmembrane transport
positive regulation of ERK1 and ERK2 cascade
positive regulation of beta-amyloid clearance
positive regulation of engulfment of apoptotic cell
negative regulation of beta-amyloid formation
positive regulation of phospholipid efflux
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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