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Product Details
PA5-103659
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ABCB11(Accession O95342), corresponding to amino acid residues N665-V715.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2852993
Product Specific Information
Antibody detects endogenous levels of total ABCB11.
Target Information
ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC member 16, MDR/TAP subfamily; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; ATP-binding cassette, sub-family B, member 11; Bile salt export pump; progressive familial intrahepatic cholestasis 2; Sister of P-glycoprotein; sister p-glycoprotein
Gene Aliases: ABC16; ABCB11; BRIC2; BSEP; Lith1; PFIC-2; PFIC2; PGY4; SPGP
UniProt ID: (Human) O95342, (Rat) O70127, (Mouse) Q9QY30
Entrez Gene ID: (Human) 8647, (Rat) 83569, (Mouse) 27413
transporter activity
ATP binding
sodium-exporting ATPase activity, phosphorylative mechanism
canalicular bile acid transmembrane transporter activity
bile acid-exporting ATPase activity
protein binding
drug transmembrane transporter activity
ATPase activity, coupled to transmembrane movement of substances
nucleotide binding
ATPase activity
ATP-binding cassette (ABC) transporter
bile acid biosynthetic process
transport
bile acid and bile salt transport
canalicular bile acid transport
sodium ion transmembrane transport
drug transmembrane transport
response to oxidative stress
metabolic process
response to drug
response to estrogen
drug export
transmembrane transport
anion transmembrane transport
organic acid transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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