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Immunogen sequence: ESPVFYVQTL QDPSKALVFE EATLSWQQTC PGIVNGALEL ERNGHASEGM TRPRDALGPE EEGNSLGPEL HKINLVVSK
ABCC11 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene.
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Protein Aliases: ATP-binding cassette protein C11; ATP-binding cassette sub-family C member 11; ATP-binding cassette transporter MRP8; ATP-binding cassette transporter sub-family C member 11; ATP-binding cassette, sub-family C (CFTR/MRP), member 11; multi-resistance protein 8; Multidrug resistance-associated protein 8
Gene Aliases: ABCC11; EWWD; MRP8; WW
UniProt ID: (Human) Q96J66
Entrez Gene ID: (Human) 85320
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