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ABCC9 Antibody (PA5-103640) in ICC/IF
Immunofluorescent analysis of ABCC9 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and ABCC9 polyclonal antibody (Product # PA5-103640) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-103640
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ABCC9(Accession O60706), corresponding to amino acid residues L1269-V1319.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2852974
Product Specific Information
Antibody detects endogenous levels of total ABCC9.
Target Information
Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-binding cassette sub-family C member 9; ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette, sub-family C (CFTR/MRP), member 9; FLJ36852; Sulfonylurea receptor 2
Gene Aliases: ABC37; ABCC9; ATFB12; CANTU; CMD1O; SUR2
UniProt ID: (Human) O60706, (Rat) Q63563
Entrez Gene ID: (Human) 10060, (Rat) 25560
transporter activity
potassium channel activity
ATP binding
sulfonylurea receptor activity
potassium channel regulator activity
anion transmembrane-transporting ATPase activity
ion channel binding
drug binding
syntaxin binding
ATPase activity, coupled to transmembrane movement of substances
identical protein binding
ATP-binding cassette (ABC) transporter
potassium ion transport
signal transduction
potassium ion import
defense response to virus
transmembrane transport
anion transmembrane transport
regulation of cardiac conduction
substrate-dependent cell migration, cell contraction
metabolic process
response to drug
potassium ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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