Proteintech

ABCG1 Polyclonal Antibody

ABCG1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ABCG1 Antibody (13578-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human cervical cancer using 13578-1-AP (ABCG1 antibody) at dilution of 1:100 (under 40x lens).

ABCG1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

13578-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 31 publications 31 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ABCG1 Fusion Protein Ag4479 (1-353 aa encoded by BC029158)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.24 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MACLMAAFS VGTAMNASSY SAEMTEPKSV CVSVDEVVSS NMEATETDLL NGHLKKVDNN LTEAQRFSSL PRRAAVNIEF RDLSYSVPEG PWWRKKGYKT LLKGISGKFN SGELVAIMGP SGAGKSTLMN ILAGYRETGM KGAVLINGLP RDLRCFRKVS CYIMQDDMLL PHLTVQEAMM VSAHLKLQEK DEGRREMVKE ILTALGLLSC ANTRTGSLSG GQRKRLAIAL ELVNNPPVMF FDEPTSGLDS ASCFQVVSLM KGLAQGGRSI ICTIHQPSAK LFELFDQLYV LSQGQCVYRG KVCNLVPYLR DLGLNCPTYH NPADFVMEVA SGEYGDQNSR LVRAVREGMC DSDH (1-353 aa encoded by BC029158)

Target Information

ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. The ABC transporter ABCG1 (ABC8) is expressed on the cell surface and in intracellular compartments of cholesterol-laden macrophages and is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. In contrast, lipid efflux in cholesterol-laden macrophages, mediated by the cholesterol acceptor HDL(3), suppresses the expression of ABCG1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Diterpenoids inhibit ox-LDL-induced foam cell formation in RAW264.7 cells by promoting ABCA1 mediated cholesterol efflux.

Frontiers in pharmacology

Zhang C,Wu X,Shi P,Ma H,Fang F,Feng Q,Zhao S,Zhang R,Huang J,Xu X,Xiao W,Cao G,Ji X

Thu Feb 02 00:00:00 EST 2023

SIAH1 ubiquitination-modified HMGCR inhibits lung cancer progression and promotes drug sensitivity through cholesterol synthesis.

Cancer cell international

Yuan H,Wu H,Cheng J,Xiong J

Sun Apr 16 00:00:00 EDT 2023

Astaxanthin Alleviates Foam Cell Formation and Promotes Cholesterol Efflux in Ox-LDL-Induced RAW264.7 Cells via CircTPP2/miR-3073b-5p/ABCA1 Pathway.

Molecules (Basel, Switzerland)

Zhang Z,Qiu Y,Li W,Tang A,Huang H,Yao W,Li H,Zou T

Fri Feb 10 00:00:00 EST 2023

Shenlian extract protected ox-LDL-loaded macrophages against ER stress by promoting LAL-LXRα mediated cholesterol flux.

Journal of ethnopharmacology

Nie CX,Du XK,Yang LN,Li MJ,Liu L,Chen Y,Yang Q,Weng XG,Cai WY,Dong Y,Zhu XX,Li Q

Tue Dec 05 00:00:00 EST 2023

Exercise Ameliorates Atherosclerosis via Up-Regulating Serum β-Hydroxybutyrate Levels.

International journal of molecular sciences

Xu Z,Zhang M,Li X,Wang Y,Du R

Wed Mar 30 00:00:00 EDT 2022

Exercise Ameliorates Atherosclerosis via Up-Regulating Serum β-Hydroxybutyrate Levels.

International journal of molecular sciences

Xu Z,Zhang M,Li X,Wang Y,Du R

Wed Mar 30 00:00:00 EDT 2022

Opuntia dillenii Haw. Polysaccharide Promotes Cholesterol Efflux in THP-1-Derived Foam Cells via the PPARγ-LXRα Signaling Pathway.

Molecules (Basel, Switzerland)

Li H,Huang Z,Zeng F

Wed Dec 07 00:00:00 EST 2022

Artemisinin and Procyanidins loaded multifunctional nanocomplexes alleviate atherosclerosis via simultaneously modulating lipid influx and cholesterol efflux.

Journal of controlled release : official journal of the Controlled Release Society

Zhou H,You P,Liu H,Fan J,Tong C,Yang A,Jiang Y,Liu B

Sat Jan 01 00:00:00 EST 2022

Artemisinin and Procyanidins loaded multifunctional nanocomplexes alleviate atherosclerosis via simultaneously modulating lipid influx and cholesterol efflux.

Journal of controlled release : official journal of the Controlled Release Society

Zhou H,You P,Liu H,Fan J,Tong C,Yang A,Jiang Y,Liu B

Sat Jan 01 00:00:00 EST 2022

Cyclodextrin boostered-high density lipoprotein for antiatherosclerosis by regulating cholesterol efflux and efferocytosis.

Carbohydrate polymers

Wang Y,Gao H,Huang X,Chen Z,Kang P,Zhou Y,Qin D,Zhang W,Liu J

Thu Sep 15 00:00:00 EDT 2022

Qihuang Zhuyu Formula Attenuates Atherosclerosis via Targeting PPARγ to Regulate Cholesterol Efflux and Endothelial Cell Inflammation.

Oxidative medicine and cellular longevity

Wang M,Xiang Q,Sun W,Zhang H,Shi R,Guo J,Tong H,Fan M,Ding Y,Shi H,Yu P,Shen L,Wang Q,Chen X

Mon Dec 19 00:00:00 EST 2022

Qihuang Zhuyu Formula Attenuates Atherosclerosis via Targeting PPARγ to Regulate Cholesterol Efflux and Endothelial Cell Inflammation.

Oxidative medicine and cellular longevity

Wang M,Xiang Q,Sun W,Zhang H,Shi R,Guo J,Tong H,Fan M,Ding Y,Shi H,Yu P,Shen L,Wang Q,Chen X

Mon Dec 19 00:00:00 EST 2022

Characterization of an Aging-Based Diagnostic Gene Signature and Molecular Subtypes With Diverse Immune Infiltrations in Atherosclerosis.

Frontiers in molecular biosciences

Zhao L,Lv F,Zheng Y,Yan L,Cao X

Tue Feb 01 00:00:00 EST 2022

Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages.

Frontiers in immunology

Mota AC,Dominguez M,Weigert A,Snodgrass RG,Namgaladze D,Brüne B

Thu Sep 23 00:00:00 EDT 2021

Targeting macrophage liver X receptors by hydrogel-encapsulated T0901317 reduces atherosclerosis without effect on hepatic lipogenesis.

British journal of pharmacology

Ma C,Feng K,Yang X,Yang Z,Wang Z,Shang Y,Fan G,Liu L,Yang S,Li X,Han J,Duan Y,Chen Y

Thu Apr 01 00:00:00 EDT 2021

Inositol hexaphosphate sensitizes hepatocellular carcinoma to oxaliplatin relating inhibition of CCN2-LRP6-β-catenin-ABCG1 signaling pathway.

Journal of Cancer

Liao X,Zhang Y,Xu B,Ali A,Liu X,Jia Q

Tue Sep 21 00:00:00 EDT 2021

Inositol hexaphosphate sensitizes hepatocellular carcinoma to oxaliplatin relating inhibition of CCN2-LRP6-β-catenin-ABCG1 signaling pathway.

Journal of Cancer

Liao X,Zhang Y,Xu B,Ali A,Liu X,Jia Q

Tue Sep 21 00:00:00 EDT 2021

Expression of the circular RNAs in astaxanthin promotes cholesterol efflux from THP-1 cells based on RNA-seq.

Genes & nutrition

Liu J,Wei Y,Lin Y,Zhang P,Zhang Z,Huang H,Wu H,Zou T

Sat Aug 28 00:00:00 EDT 2021

Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.

Autophagy

Matsuda J,Takahashi A,Takabatake Y,Sakai S,Minami S,Yamamoto T,Fujimura R,Namba-Hamano T,Yonishi H,Nakamura J,Kimura T,Kaimori JY,Matsui I,Takahashi M,Nakao M,Izumi Y,Bamba T,Matsusaka T,Niimura F,Yanagita M,Yoshimori T,Isaka Y

Thu Oct 01 00:00:00 EDT 2020

Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma.

BMC cancer

Liao X,Song G,Xu Z,Bu Y,Chang F,Jia F,Xiao X,Ren X,Zhang M,Jia Q

Mon Jan 13 00:00:00 EST 2020

Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma.

BMC cancer

Liao X,Song G,Xu Z,Bu Y,Chang F,Jia F,Xiao X,Ren X,Zhang M,Jia Q

Mon Jan 13 00:00:00 EST 2020

Regulation mechanism of silkworm pupa oil PUFAs on cholesterol metabolism in hepatic cell L-02.

Journal of the science of food and agriculture

Luo Y,Wang L,Lv Y,Wu X,Hou C,Li J

Sun Mar 15 00:00:00 EDT 2020

ABCG1 Attenuates Oxidative Stress Induced by H₂O₂ through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells.

Analytical cellular pathology (Amsterdam)

Xue J,Fan J,Li Y,Wu W,Yan Q,Zheng Q

Thu Aug 26 00:00:00 EDT 2021

Food with calorie restriction reduces the development of atherosclerosis in apoE-deficient mice.

Biochemical and biophysical research communications

Yang J,Zeng P,Liu L,Yu M,Su J,Yan Y,Ma J,Hu W,Yang X,Han J,Duan Y,Chen Y

Thu Apr 02 00:00:00 EDT 2020

Structures and anti-atherosclerotic effects of 1,6-α-glucans from Fructus Corni.

International journal of biological macromolecules

Zhang XW,Sui Y,Liu XX,Fu CY,Qiao YH,Liu WJ,Li ZZ,Li XQ,Cao W

Thu Oct 15 00:00:00 EDT 2020

The circFASN/miR-33a pathway participates in tacrolimus-induced dysregulation of hepatic triglyceride homeostasis.

Signal transduction and targeted therapy

Zhang C,Chen K,Wei R,Fan G,Cai X,Xu L,Cen B,Wang J,Xie H,Zheng S,Xu X

Fri Mar 27 00:00:00 EDT 2020

Metformin ameliorates Ox-LDL-induced foam cell formation in raw264.7 cells by promoting ABCG-1 mediated cholesterol efflux.

Life sciences

He X,Chen X,Wang L,Wang W,Liang Q,Yi L,Wang Y,Gao Q

Tue Jan 01 00:00:00 EST 2019

Metformin ameliorates Ox-LDL-induced foam cell formation in raw264.7 cells by promoting ABCG-1 mediated cholesterol efflux.

Life sciences

He X,Chen X,Wang L,Wang W,Liang Q,Yi L,Wang Y,Gao Q

Tue Jan 01 00:00:00 EST 2019

ALDH2 deficiency inhibits Ox-LDL induced foam cell formation via suppressing CD36 expression.

Biochemical and biophysical research communications

Wei S,Zhang L,Zhao Y,Dong Q,Pan C,Li C,He D,Yuan Q,Xu F,Chen Y

Tue Apr 23 00:00:00 EDT 2019

Low-dose PCB126 compromises circadian rhythms associated with disordered glucose and lipid metabolism in mice.

Environment international

Shen X,Chen Y,Zhang J,Yan X,Liu W,Guo Y,Shan Q,Liu S

Mon Jul 01 00:00:00 EDT 2019

Thioredoxin-1 promotes macrophage reverse cholesterol transport and protects liver from steatosis.

Biochemical and biophysical research communications

Wang X,Zhao H,Yan W,Liu Y,Yin T,Wang S,Fan M,Li C,Zhang L,Tao L

Tue Sep 03 00:00:00 EDT 2019

Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy.

British journal of pharmacology

Ma C,Zhang W,Yang X,Liu Y,Liu L,Feng K,Zhang X,Yang S,Sun L,Yu M,Yang J,Li X,Hu W,Miao RQ,Zhu Y,Li L,Han J,Chen Y,Duan Y

Tue May 01 00:00:00 EDT 2018

Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy.

British journal of pharmacology

Ma C,Zhang W,Yang X,Liu Y,Liu L,Feng K,Zhang X,Yang S,Sun L,Yu M,Yang J,Li X,Hu W,Miao RQ,Zhu Y,Li L,Han J,Chen Y,Duan Y

Tue May 01 00:00:00 EDT 2018

25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism.

Journal of lipid research

Liu Y,Wei Z,Ma X,Yang X,Chen Y,Sun L,Ma C,Miao QR,Hajjar DP,Han J,Duan Y

Thu Mar 01 00:00:00 EST 2018

25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism.

Journal of lipid research

Liu Y,Wei Z,Ma X,Yang X,Chen Y,Sun L,Ma C,Miao QR,Hajjar DP,Han J,Duan Y

Thu Mar 01 00:00:00 EST 2018

Early Presymptomatic Changes in the Proteome of Mitochondria-Associated Membrane in the APP/PS1 Mouse Model of Alzheimer's Disease.

Molecular neurobiology

Völgyi K,Badics K,Sialana FJ,Gulyássy P,Udvari EB,Kis V,Drahos L,Lubec G,Kékesi KA,Juhász G

Mon Oct 01 00:00:00 EDT 2018

Early Presymptomatic Changes in the Proteome of Mitochondria-Associated Membrane in the APP/PS1 Mouse Model of Alzheimer's Disease.

Molecular neurobiology

Völgyi K,Badics K,Sialana FJ,Gulyássy P,Udvari EB,Kis V,Drahos L,Lubec G,Kékesi KA,Juhász G

Mon Oct 01 00:00:00 EDT 2018

Effects of Porphyromonas gingivalis lipopolysaccharide on the expression of key genes involved in cholesterol metabolism in macrophages.

Archives of medical science : AMS

Liu F,Wang Y,Xu J,Liu F,Hu R,Deng H

Sat Oct 01 00:00:00 EDT 2016

Effects of Porphyromonas gingivalis lipopolysaccharide on the expression of key genes involved in cholesterol metabolism in macrophages.

Archives of medical science : AMS

Liu F,Wang Y,Xu J,Liu F,Hu R,Deng H

Sat Oct 01 00:00:00 EDT 2016

MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition.

Biochimica et biophysica acta

Zhang L,Chen Y,Yang X,Yang J,Cao X,Li X,Li L,Miao QR,Hajjar DP,Duan Y,Han J

Thu Sep 01 00:00:00 EDT 2016

MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition.

Biochimica et biophysica acta

Zhang L,Chen Y,Yang X,Yang J,Cao X,Li X,Li L,Miao QR,Hajjar DP,Duan Y,Han J

Thu Sep 01 00:00:00 EDT 2016

MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition.

Biochimica et biophysica acta

Zhang L,Chen Y,Yang X,Yang J,Cao X,Li X,Li L,Miao QR,Hajjar DP,Duan Y,Han J

Thu Sep 01 00:00:00 EDT 2016

MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition.

Biochimica et biophysica acta

Zhang L,Chen Y,Yang X,Yang J,Cao X,Li X,Li L,Miao QR,Hajjar DP,Duan Y,Han J

Thu Sep 01 00:00:00 EDT 2016

Mitochondrion-Targeted Peptide SS-31 Inhibited Oxidized Low-Density Lipoproteins-Induced Foam Cell Formation through both ROS Scavenging and Inhibition of Cholesterol Influx in RAW264.7 Cells.

Molecules (Basel, Switzerland)

Hao S,Ji J,Zhao H,Shang L,Wu J,Li H,Qiao T,Li K

Tue Dec 01 00:00:00 EST 2015

Mitochondrion-Targeted Peptide SS-31 Inhibited Oxidized Low-Density Lipoproteins-Induced Foam Cell Formation through both ROS Scavenging and Inhibition of Cholesterol Influx in RAW264.7 Cells.

Molecules (Basel, Switzerland)

Hao S,Ji J,Zhao H,Shang L,Wu J,Li H,Qiao T,Li K

Tue Dec 01 00:00:00 EST 2015

ATP-binding cassette transporter G1 protects against endothelial dysfunction induced by high glucose.

Diabetes research and clinical practice

Xue J,Wang C,Zhu C,Li Y

Mon Jul 01 00:00:00 EDT 2013

ATP-binding cassette transporter G1 protects against endothelial dysfunction induced by high glucose.

Diabetes research and clinical practice

Xue J,Wang C,Zhu C,Li Y

Mon Jul 01 00:00:00 EDT 2013

ABCG1 deficiency promotes endothelial apoptosis by endoplasmic reticulum stress-dependent pathway.

The journal of physiological sciences : JPS

Xue J,Wei J,Dong X,Zhu C,Li Y,Song A,Liu Z

Fri Nov 01 00:00:00 EDT 2013

ABCG1 deficiency promotes endothelial apoptosis by endoplasmic reticulum stress-dependent pathway.

The journal of physiological sciences : JPS

Xue J,Wei J,Dong X,Zhu C,Li Y,Song A,Liu Z

Fri Nov 01 00:00:00 EDT 2013

DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.

Biochimica et biophysica acta

Zhang L,Jiang M,Shui Y,Chen Y,Wang Q,Hu W,Ma X,Li X,Liu X,Cao X,Liu M,Duan Y,Han J

Sat Jun 01 00:00:00 EDT 2013

DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.

Biochimica et biophysica acta

Zhang L,Jiang M,Shui Y,Chen Y,Wang Q,Hu W,Ma X,Li X,Liu X,Cao X,Liu M,Duan Y,Han J

Sat Jun 01 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: ABC transporter 8; ATP-binding cassette 8; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; ATP-binding cassette, sub-family G (WHITE), member 1; ATP-binding cassette, subfamily G, member 1; homolog of Drosophila white; MGC34313; White protein homolog; white protein homolog (ATP-binding cassette transporter 8)

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Gene Aliases: ABC8; ABCG1; AW413978; White; WHITE1; WHT1

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UniProt ID: (Human) P45844, (Mouse) Q64343

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Entrez Gene ID: (Human) 9619, (Rat) 85264, (Mouse) 11307

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Function(s)

ATP binding phospholipid binding phospholipid transporter activity cholesterol binding cholesterol transporter activity toxin transporter activity sterol-transporting ATPase activity glycoprotein transporter activity protein homodimerization activity ADP binding protein heterodimerization activity protein dimerization activity nucleotide binding ATPase activity ATP-binding cassette (ABC) transporter primary active transporter transporter

Process(es)

regulation of transcription, DNA-templated cholesterol metabolic process detection of hormone stimulus response to organic substance negative regulation of macrophage derived foam cell differentiation regulation of cholesterol esterification positive regulation of cholesterol efflux negative regulation of cholesterol storage intracellular cholesterol transport cholesterol efflux phospholipid efflux response to lipid low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling glycoprotein transport lipoprotein metabolic process cholesterol homeostasis amyloid precursor protein catabolic process reverse cholesterol transport positive regulation of cholesterol biosynthetic process transmembrane transport phospholipid homeostasis response to high density lipoprotein particle toxin transport negative regulation of lipid storage cholesterol transport transport lipid transport

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ABCG1 Polyclonal Antibody

ABCG1 Antibody (13578-1-AP) in IHC (P)

Product Details

13578-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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