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Product Details
PA5-72939
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Hamster,
Human,
Mouse,
Non-human primate,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide made to an internal region of human ABCG1 (between residues 300-400). [UniProt# P45844]
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2718793
Target Information
ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. The ABC transporter ABCG1 (ABC8) is expressed on the cell surface and in intracellular compartments of cholesterol-laden macrophages and is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. In contrast, lipid efflux in cholesterol-laden macrophages, mediated by the cholesterol acceptor HDL(3), suppresses the expression of ABCG1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC transporter 8; ATP-binding cassette 8; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; ATP-binding cassette, sub-family G (WHITE), member 1; ATP-binding cassette, subfamily G, member 1; homolog of Drosophila white; MGC34313; White protein homolog; white protein homolog (ATP-binding cassette transporter 8)
Gene Aliases: ABC8; ABCG1; AW413978; I79_011524; White; WHITE1; WHT1
UniProt ID: (Human) P45844, (Mouse) Q64343
Entrez Gene ID: (Human) 9619, (Rabbit) 103346773, (Rat) 85264, (Mouse) 11307, (Chinese hamster) 100759619
ATP binding
phospholipid binding
phospholipid transporter activity
cholesterol binding
cholesterol transporter activity
toxin transporter activity
sterol-transporting ATPase activity
glycoprotein transporter activity
protein homodimerization activity
ADP binding
protein heterodimerization activity
protein dimerization activity
nucleotide binding
ATPase activity
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
regulation of transcription, DNA-templated
cholesterol metabolic process
detection of hormone stimulus
response to organic substance
negative regulation of macrophage derived foam cell differentiation
regulation of cholesterol esterification
positive regulation of cholesterol efflux
negative regulation of cholesterol storage
intracellular cholesterol transport
cholesterol efflux
phospholipid efflux
response to lipid
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
glycoprotein transport
lipoprotein metabolic process
cholesterol homeostasis
amyloid precursor protein catabolic process
reverse cholesterol transport
positive regulation of cholesterol biosynthetic process
transmembrane transport
phospholipid homeostasis
response to high density lipoprotein particle
toxin transport
negative regulation of lipid storage
cholesterol transport
transport
lipid transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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