Proteintech

ACE Polyclonal Antibody

ACE Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

ACE Antibody (24743-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human lung tissue slide using (Product # 24743-1-AP) (ACE antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

ACE Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

24743-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ACE Fusion Protein Ag20654 (390-739 aa encoded by BC036375)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.36 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: FYNGKDFRI KQCTTVNLED LVVAHHEMGH IQYFMQYKDL PVALREGANP GFHEAIGDVL ALSVSTPKHL HSLNLLSSEG GSDEHDINFL MKMALDKIAF IPFSYLVDQW RWRVFDGSIT KENYNQEWWS LRLKYQGLCP PVPRTQGDFD PGAKFHIPSS VPYIRYFVSF IIQFQFHEAL CQAAGHTGPL HKCDIYQSKE AGQRLATAMK LGFSRPWPEA MQLITGQPNM SASAMLSYFK PLLDWLRTEN ELHGEKLGWP QYNWTPNSDD FYNETETKIF LQFYDQTGIW DHGAPHLLPP SQARGTREAP VYMSKRAASS GPPGSPKLPP AAQGHGEVPV HDLLWHPGPP V (390-739 aa encoded by BC036375)

Target Information

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes-the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Losartan attenuates acetic acid enema-induced visceral hypersensitivity by inhibiting the ACE1/Ang II/AT1 receptor axis in enteric glial cells.

European journal of pharmacology

Sun Y,Liu X,Wang L,Li L,Quan X,Shi H,Wang T,Mei L,Chen Y,Zhang Y,Li J,Meng R,Wang J,Dai F

Fri May 05 00:00:00 EDT 2023

Renal CD81 interacts with sodium potassium 2 chloride cotransporter and sodium chloride cotransporter in rats with lipopolysaccharide-induced preeclampsia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Wang P,Zhu G,Wu Q,Shen L,Liu D,Wang Z,Wang W,Ren Z,Jia Y,Liu M,Xue Y,Ji D,Hu Y,Yu Y,Wang X

Sat Apr 01 00:00:00 EDT 2023

Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries.

European journal of pharmacology

Zhou W,Wang C,Zhang B,Gou S

Wed Jul 05 00:00:00 EDT 2023

Azelaic Acid Regulates the Renin-Angiotensin System and Improves Colitis Based on Network Pharmacology and Experimentation.

ACS omega

Liao Y,Wu X,Luo W,Chen J,Huang Y,Ma K,Zhang C,Wang J,Yang Y,Deng M,Wang X

Tue May 02 00:00:00 EDT 2023

Azelaic Acid Regulates the Renin-Angiotensin System and Improves Colitis Based on Network Pharmacology and Experimentation.

ACS omega

Liao Y,Wu X,Luo W,Chen J,Huang Y,Ma K,Zhang C,Wang J,Yang Y,Deng M,Wang X

Tue May 02 00:00:00 EDT 2023

Non-Invasive Local Acoustic Therapy Ameliorates Diabetic Heart Fibrosis by Suppressing ACE-Mediated Oxidative Stress and Inflammation in Cardiac Fibroblasts.

Cardiovascular drugs and therapy

Weng L,Li L,Zhao K,Xu T,Mao Y,Shu H,Chen X,Chen J,Wu J,Guo X,Tu J,Zhang D,Sun W,Kong X

Wed Jun 01 00:00:00 EDT 2022

TMPRSS2 Expression and Activity Modulation by Sex-Related Hormones in Lung Calu-3 Cells: Impact on Gender-Specific SARS-CoV-2 Infection.

Frontiers in endocrinology

Treppiedi D,Marra G,Di Muro G,Catalano R,Mangili F,Esposito E,Barbieri AM,Arosio M,Mantovani G,Peverelli E

Mon Jun 20 00:00:00 EDT 2022

TMT-based quantitative N-glycoproteomic analysis reveals glycoprotein protection can improve the quality of frozen bovine sperm.

International journal of biological macromolecules

Wang N,Yang M,He D,Li X,Zhang X,Han B,Liu C,Hai C,Li G,Zhao Y

Sat Oct 01 00:00:00 EDT 2022

Sodium butyrate exerts antioxidant stress effects and attenuates Aβ_25-35-induced cytotoxicity in PC12 cells.

Archives of biochemistry and biophysics

Yuan B,Liu M,Gong Y,Wang Z,Jin X,Xie G,Zhu M,Zhang X,Luo S,Qu Q,Zhu Y,Wang M,Jin Y,Li B,Wang W

Wed Nov 30 00:00:00 EST 2022

Tissue Renin-Angiotensin System (tRAS) Induce Intervertebral Disc Degeneration by Activating Oxidative Stress and Inflammatory Reaction.

Oxidative medicine and cellular longevity

Sun K,Sun X,Sun J,Jiang Y,Lin F,Kong F,Li F,Zhu J,Huan L,Zheng B,Wang Y,Zou W,Gao L,Xu X,Shi J

Tue Jan 11 00:00:00 EST 2022

Tissue Renin-Angiotensin System (tRAS) Induce Intervertebral Disc Degeneration by Activating Oxidative Stress and Inflammatory Reaction.

Oxidative medicine and cellular longevity

Sun K,Sun X,Sun J,Jiang Y,Lin F,Kong F,Li F,Zhu J,Huan L,Zheng B,Wang Y,Zou W,Gao L,Xu X,Shi J

Tue Jan 11 00:00:00 EST 2022

Tissue Renin-Angiotensin System (tRAS) Induce Intervertebral Disc Degeneration by Activating Oxidative Stress and Inflammatory Reaction.

Oxidative medicine and cellular longevity

Sun K,Sun X,Sun J,Jiang Y,Lin F,Kong F,Li F,Zhu J,Huan L,Zheng B,Wang Y,Zou W,Gao L,Xu X,Shi J

Tue Jan 11 00:00:00 EST 2022

Tissue Renin-Angiotensin System (tRAS) Induce Intervertebral Disc Degeneration by Activating Oxidative Stress and Inflammatory Reaction.

Oxidative medicine and cellular longevity

Sun K,Sun X,Sun J,Jiang Y,Lin F,Kong F,Li F,Zhu J,Huan L,Zheng B,Wang Y,Zou W,Gao L,Xu X,Shi J

Tue Jan 11 00:00:00 EST 2022

H. sinensis mycelium inhibits epithelial-mesenchymal transition by inactivating the midkine pathway in pulmonary fibrosis.

Frontiers of medicine

Lu L,Zhu H,Wang H,Liang H,Hou Y,Dou H

Thu Apr 01 00:00:00 EDT 2021

MiR155-5p Inhibits Cell Migration and Oxidative Stress in Vascular Smooth Muscle Cells of Spontaneously Hypertensive Rats.

Antioxidants (Basel, Switzerland)

Wu N,Ye C,Zheng F,Wan GW,Wu LL,Chen Q,Li YH,Kang YM,Zhu GQ

Sun Mar 01 00:00:00 EST 2020

Therapeutic effects of higenamine combined with [6]-gingerol on chronic heart failure induced by doxorubicin via ameliorating mitochondrial function.

Journal of cellular and molecular medicine

Wen J,Zhang L,Wang J,Wang J,Wang L,Wang R,Li R,Liu H,Wei S,Li H,Zou W,Zhao Y

Wed Apr 01 00:00:00 EDT 2020

RhoA-Rho associated kinase signaling leads to renin-angiotensin system imbalance and angiotensin converting enzyme 2 has a protective role in acute pulmonary embolism.

Thrombosis research

Xu X,Shi L,Ma X,Su H,Ma G,Wu X,Ying K,Zhang R

Mon Apr 01 00:00:00 EDT 2019

Network pharmacology-based strategy for predicting active ingredients and potential targets of Yangxinshi tablet for treating heart failure.

Journal of ethnopharmacology

Chen L,Cao Y,Zhang H,Lv D,Zhao Y,Liu Y,Ye G,Chai Y

Tue Jun 12 00:00:00 EDT 2018

Network pharmacology-based strategy for predicting active ingredients and potential targets of Yangxinshi tablet for treating heart failure.

Journal of ethnopharmacology

Chen L,Cao Y,Zhang H,Lv D,Zhao Y,Liu Y,Ye G,Chai Y

Tue Jun 12 00:00:00 EDT 2018

Bioinformatics

Protein Aliases: ACE; angiotensin 1 converting enzyme 1; angiotensin converting enzyme, somatic isoform; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript; angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1); Angiotensin-converting enzyme; carboxycathepsin; CD143; CD143 antigen; dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); Dipeptidyl carboxypeptidase I; dipeptidyl peptidase; Kininase II; MGC26566; peptidase P; testicular ECA

View more View less

Gene Aliases: ACE; ACE1; AW208573; CD143; DCP; DCP1; ICH; MVCD3; StsRR92

View more View less

UniProt ID: (Human) P12821, (Mouse) P09470, (Rat) P47820

View more View less

Entrez Gene ID: (Human) 1636, (Mouse) 11421, (Rat) 24310

View more View less

Function(s)

endopeptidase activity carboxypeptidase activity drug binding metallopeptidase activity exopeptidase activity tripeptidyl-peptidase activity peptidyl-dipeptidase activity zinc ion binding chloride ion binding mitogen-activated protein kinase kinase binding bradykinin receptor binding mitogen-activated protein kinase binding metallodipeptidase activity actin binding protein binding peptidase activity lytic transglycosylase activity mannosidase activity mannosyl-oligosaccharide mannosidase activity galactosidase activity glucosidase activity trehalase activity fucosidase activity hexosaminidase activity amylase activity hydrolase activity dextrin alpha-glucosidase activity starch alpha-glucosidase activity metal ion binding beta-glucanase activity beta-6-sulfate-N-acetylglucosaminidase activity glucan endo-1,4-beta-glucosidase activity metalloprotease protease protein modifying enzyme

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

ACE Polyclonal Antibody

ACE Antibody (24743-1-AP) in IHC (P)

Product Details

24743-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!