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Product Details
PA5-47146
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse ACE/CD143 Leu35-Gln1264
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2609583
Product Specific Information
In Western blots, approximately 25% cross-reactivity with recombinant human ACE and 5% cross-reactivity with recombinant human ACE-2 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes-the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACE; Angiotensin-converting enzyme; CD143; Dipeptidyl carboxypeptidase I; dipeptidyl peptidase; Kininase II; MGC26566
Gene Aliases: Ace; AW208573; CD143; Dcp1
UniProt ID: (Mouse) P09470
Entrez Gene ID: (Mouse) 11421
actin binding
endopeptidase activity
carboxypeptidase activity
protein binding
drug binding
peptidase activity
metallopeptidase activity
exopeptidase activity
tripeptidyl-peptidase activity
peptidyl-dipeptidase activity
zinc ion binding
lytic transglycosylase activity
mannosidase activity
mannosyl-oligosaccharide mannosidase activity
galactosidase activity
glucosidase activity
trehalase activity
fucosidase activity
hexosaminidase activity
amylase activity
hydrolase activity
chloride ion binding
mitogen-activated protein kinase kinase binding
bradykinin receptor binding
dextrin alpha-glucosidase activity
starch alpha-glucosidase activity
metal ion binding
mitogen-activated protein kinase binding
beta-glucanase activity
beta-6-sulfate-N-acetylglucosaminidase activity
glucan endo-1,4-beta-glucosidase activity
metalloprotease
protease
protein modifying enzyme
kidney development
neutrophil mediated immunity
regulation of systemic arterial blood pressure by renin-angiotensin
positive regulation of systemic arterial blood pressure
proteolysis
peptide metabolic process
spermatogenesis
regulation of blood pressure
posttranscriptional regulation of gene expression
negative regulation of gene expression
bradykinin catabolic process
regulation of smooth muscle cell migration
sensory perception of pain
organ regeneration
negative regulation of protein binding
positive regulation of protein binding
response to lipopolysaccharide
vasoconstriction
hormone catabolic process
eating behavior
positive regulation of apoptotic process
peptide catabolic process
lung alveolus development
beta-amyloid metabolic process
arachidonic acid secretion
positive regulation of inflammatory response
positive regulation of neurogenesis
heart contraction
regulation of angiotensin metabolic process
angiogenesis involved in coronary vascular morphogenesis
positive regulation of protein tyrosine kinase activity
cell proliferation in bone marrow
negative regulation of calcium ion import
positive regulation of peptidyl-tyrosine autophosphorylation
regulation of hematopoietic stem cell proliferation
negative regulation of gap junction assembly
positive regulation of peptidyl-cysteine S-nitrosylation
Performance Guarantee
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