Invitrogen

ACE Recombinant Rabbit Monoclonal Antibody (ARC0577)

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-35099

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunoprecipitation (IP)

1:50-1:200
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC0577

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1200-1306 of human ACE1 (P12821)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849004

Product Specific Information

Immunogen sequence: YFKPLLDWLR TENELHGEKL GWPQYNWTPN SARSEGPLPD SGRVSFLGLD LDAQQARVGQ WLLLFLGIAL LVATLGLSQR LFSIRHRSLH RHSHGPQFGS EVELRHS

Target Information

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes-the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ACE; angiotensin 1 converting enzyme 1; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1); Angiotensin-converting enzyme; CD143; Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); Dipeptidyl carboxypeptidase I; dipeptidyl peptidase; Kininase II; MGC26566

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Gene Aliases: Ace; AW208573; CD143; Dcp1; StsRR92

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UniProt ID: (Mouse) P09470, (Rat) P47820

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Entrez Gene ID: (Mouse) 11421, (Rat) 24310

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Function(s)
actin binding endopeptidase activity carboxypeptidase activity protein binding drug binding peptidase activity metallopeptidase activity exopeptidase activity tripeptidyl-peptidase activity peptidyl-dipeptidase activity zinc ion binding lytic transglycosylase activity mannosidase activity mannosyl-oligosaccharide mannosidase activity galactosidase activity glucosidase activity trehalase activity fucosidase activity hexosaminidase activity amylase activity hydrolase activity chloride ion binding mitogen-activated protein kinase kinase binding bradykinin receptor binding dextrin alpha-glucosidase activity starch alpha-glucosidase activity metal ion binding mitogen-activated protein kinase binding beta-glucanase activity beta-6-sulfate-N-acetylglucosaminidase activity glucan endo-1,4-beta-glucosidase activity metalloprotease protease protein modifying enzyme
Process(es)
kidney development neutrophil mediated immunity regulation of systemic arterial blood pressure by renin-angiotensin positive regulation of systemic arterial blood pressure proteolysis peptide metabolic process spermatogenesis regulation of blood pressure posttranscriptional regulation of gene expression negative regulation of gene expression bradykinin catabolic process regulation of smooth muscle cell migration sensory perception of pain organ regeneration negative regulation of protein binding positive regulation of protein binding response to lipopolysaccharide vasoconstriction hormone catabolic process eating behavior positive regulation of apoptotic process peptide catabolic process lung alveolus development beta-amyloid metabolic process arachidonic acid secretion positive regulation of inflammatory response positive regulation of neurogenesis heart contraction regulation of angiotensin metabolic process angiogenesis involved in coronary vascular morphogenesis positive regulation of protein tyrosine kinase activity cell proliferation in bone marrow negative regulation of calcium ion import positive regulation of peptidyl-tyrosine autophosphorylation regulation of hematopoietic stem cell proliferation negative regulation of gap junction assembly positive regulation of peptidyl-cysteine S-nitrosylation response to hypoxia brain development female pregnancy aging male gonad development lung development response to nutrient levels response to laminar fluid shear stress response to drug cellular response to glucose stimulus response to dexamethasone response to thyroid hormone
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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