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Invitrogen
ACE Recombinant Rabbit Monoclonal Antibody (JM59-32)
Advanced Verification
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
Product Details
MA5-32741
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JM59-32
Immunogen
Synthetic peptide within Human ACE aa 1257-1306
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2810018
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes-the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ACE; angiotensin 1 converting enzyme 1; angiotensin converting enzyme, somatic isoform; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript; angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1); Angiotensin-converting enzyme; carboxycathepsin; CD143; CD143 antigen; dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); Dipeptidyl carboxypeptidase I; dipeptidyl peptidase; Kininase II; MGC26566; peptidase P; testicular ECA
Gene Aliases: ACE; ACE1; AW208573; CD143; DCP; DCP1; ICH; MVCD3; StsRR92
UniProt ID: (Human) P12821, (Mouse) P09470, (Rat) P47820
Entrez Gene ID: (Human) 1636, (Mouse) 11421, (Rat) 24310
endopeptidase activity
carboxypeptidase activity
drug binding
metallopeptidase activity
exopeptidase activity
tripeptidyl-peptidase activity
peptidyl-dipeptidase activity
zinc ion binding
chloride ion binding
mitogen-activated protein kinase kinase binding
bradykinin receptor binding
mitogen-activated protein kinase binding
metallodipeptidase activity
actin binding
protein binding
peptidase activity
lytic transglycosylase activity
mannosidase activity
mannosyl-oligosaccharide mannosidase activity
galactosidase activity
glucosidase activity
trehalase activity
fucosidase activity
hexosaminidase activity
amylase activity
hydrolase activity
dextrin alpha-glucosidase activity
starch alpha-glucosidase activity
metal ion binding
beta-glucanase activity
beta-6-sulfate-N-acetylglucosaminidase activity
glucan endo-1,4-beta-glucosidase activity
metalloprotease
protease
protein modifying enzyme
kidney development
blood vessel remodeling
angiotensin maturation
angiotensin catabolic process in blood
regulation of renal output by angiotensin
neutrophil mediated immunity
antigen processing and presentation of peptide antigen via MHC class I
regulation of systemic arterial blood pressure by renin-angiotensin
spermatogenesis
regulation of blood pressure
regulation of smooth muscle cell migration
regulation of vasoconstriction
mononuclear cell proliferation
regulation of vasodilation
hormone catabolic process
peptide catabolic process
beta-amyloid metabolic process
arachidonic acid secretion
heart contraction
regulation of angiotensin metabolic process
hematopoietic stem cell differentiation
positive regulation of protein tyrosine kinase activity
cell proliferation in bone marrow
positive regulation of peptidyl-tyrosine autophosphorylation
regulation of hematopoietic stem cell proliferation
negative regulation of gap junction assembly
positive regulation of peptidyl-cysteine S-nitrosylation
positive regulation of systemic arterial blood pressure
proteolysis
peptide metabolic process
posttranscriptional regulation of gene expression
negative regulation of gene expression
bradykinin catabolic process
sensory perception of pain
organ regeneration
negative regulation of protein binding
positive regulation of protein binding
response to lipopolysaccharide
vasoconstriction
eating behavior
positive regulation of apoptotic process
lung alveolus development
positive regulation of inflammatory response
positive regulation of neurogenesis
angiogenesis involved in coronary vascular morphogenesis
negative regulation of calcium ion import
response to hypoxia
brain development
female pregnancy
aging
male gonad development
lung development
response to nutrient levels
response to laminar fluid shear stress
response to drug
cellular response to glucose stimulus
response to dexamethasone
response to thyroid hormone
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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