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Product Details
TA812212
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2G5
Immunogen
Human recombinant protein fragment corresponding to amino acids 642-1230 of human ACE produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes-the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACE; angiotensin converting enzyme, somatic isoform; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript; Angiotensin-converting enzyme; carboxycathepsin; CD143; CD143 antigen; dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase I; Kininase II; MGC26566; peptidase P; testicular ECA
Gene Aliases: ACE; ACE1; CD143; DCP; DCP1; ICH; MVCD3
UniProt ID: (Human) P12821
Entrez Gene ID: (Human) 1636
endopeptidase activity
carboxypeptidase activity
drug binding
metallopeptidase activity
exopeptidase activity
tripeptidyl-peptidase activity
peptidyl-dipeptidase activity
zinc ion binding
chloride ion binding
mitogen-activated protein kinase kinase binding
bradykinin receptor binding
mitogen-activated protein kinase binding
metallodipeptidase activity
metalloprotease
protease
protein modifying enzyme
kidney development
blood vessel remodeling
angiotensin maturation
angiotensin catabolic process in blood
regulation of renal output by angiotensin
neutrophil mediated immunity
antigen processing and presentation of peptide antigen via MHC class I
regulation of systemic arterial blood pressure by renin-angiotensin
spermatogenesis
regulation of blood pressure
regulation of smooth muscle cell migration
regulation of vasoconstriction
mononuclear cell proliferation
regulation of vasodilation
hormone catabolic process
peptide catabolic process
beta-amyloid metabolic process
arachidonic acid secretion
heart contraction
regulation of angiotensin metabolic process
hematopoietic stem cell differentiation
positive regulation of protein tyrosine kinase activity
cell proliferation in bone marrow
positive regulation of peptidyl-tyrosine autophosphorylation
regulation of hematopoietic stem cell proliferation
negative regulation of gap junction assembly
positive regulation of peptidyl-cysteine S-nitrosylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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