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Product Details
15633-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ACOT2 Fusion Protein Ag8093 (222-483 aa encoded by BC006335)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: IVDMFGTGG GLLEYRASLL AGKGFAVMAL AYYNYEDLPK TMETLHLEYF EEAMNYLLSH PEVKGPGVGL LGISKGGELC LSMASFLKGI TAAVVINGSV ANVGGTLRYK GETLPPVGVN RNRIKVTKDG YADIVDVLNS PLEGPDQKSF IPVERAESTF LFLVGQDDHN WKSEFYANEA CKRLQAHGRR KPQIICYPET GHYIEPPYFP LCRASLHALV GSPIIWGGEP RAHVMAQVDA WKQLQTFFHK HLGGHEGTIP SKV (222-483 aa encoded by BC006335)
Target Information
Acyl-CoA thioesterases (ACOTs) are a group of enzymes that catalyze the hydrolysis of acyl-CoA to form coenzyme A (CoA) and a free fatty acid. Through their catalytic activity, ACOTs are able to regulate the level of fatty acids and acyl-CoAs within the cell. ACOT1 (acyl-CoA thioesterase 1, also known as CTE1) and ACOT2 (acyl-CoA thioesterase 2, also known as PTE2) are members of the ACOT family and exhibit different cellular localization, with ACOT1 existing as a monomer in the cytoplasm and ACOT2 localized primarily to mitochondria. Characteristic of most ACOT proteins, ACOT1 and ACOT2 catalyze the conversion of Palmitoyl-CoA and water to free CoA and palmitate, a reaction that is important for the regulation of intercellular fatty acid levels. ACOT2 is expressed as multiple alternatively spliced isoforms and, like ACOT1, is encoded by a gene which maps to human chromosome 14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Acyl coenzyme A thioester hydrolase; Acyl-CoA thioesterase 2; Acyl-coenzyme A thioester hydrolase 2a; Acyl-coenzyme A thioesterase 2, mitochondrial; ARTISt/p43; CTE Ia; CTE-Ia; Long-chain acyl-CoA thioesterase 2; mitochondrial acyl-CoA thioesterase 1; MTE-I; peroxisomal long-chain acyl-coA thioesterase 2; Very-long-chain acyl-CoA thioesterase; ZAP128
Gene Aliases: AA571646; ACOT2; CTE-IA; CTE1A; MTE-I; MTE1; PTE2; PTE2A; ZAP128
UniProt ID: (Human) P49753, (Mouse) Q9QYR9
Entrez Gene ID: (Human) 10965, (Mouse) 171210, (Rat) 192272
very long-chain fatty acid metabolic process
long-chain fatty acid metabolic process
acyl-CoA metabolic process
long-chain fatty-acyl-CoA biosynthetic process
response to hypoxia
very long-chain fatty acid catabolic process
response to hormone
response to nutrient levels
response to drug
response to epidermal growth factor
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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