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ACOX1 Antibody (PA5-114813) in IHC (P)
Immunohistochemistry analysis of ACOX1 in mouse testis tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-114813) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Product Details
PA5-114813
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ACOX1(Accession Q15067), corresponding to amino acid residues S438-K488.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2899449
Product Specific Information
Antibody detects endogenous levels of total ACOX1.
Target Information
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACO; acyl-CoA oxidase 1, palmitoyl; acyl-CoA oxidase, straight-chain; acyl-Coenzyme A oxidase 1, palmitoyl; AOX; Palmitoyl-CoA oxidase; Peroxisomal acyl-coenzyme A oxidase 1; Peroxisomal fatty acyl-CoA oxidase; peroxisomal fatty acyl-coenzyme A oxidase; peroxisomal straight-chain Acyl-CoA oxidase; SCOX; Straight-chain acyl-CoA oxidase
Gene Aliases: ACOX; ACOX1; AOX; D130055E20Rik; PALMCOX; Paox; RATACOA1; SCOX
UniProt ID: (Human) Q15067, (Rat) P07872, (Mouse) Q9R0H0
Entrez Gene ID: (Human) 51, (Rat) 50681, (Mouse) 11430
fatty-acyl-CoA binding
acyl-CoA dehydrogenase activity
acyl-CoA oxidase activity
receptor binding
electron carrier activity
PDZ domain binding
protein N-terminus binding
flavin adenine dinucleotide binding
oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor
fatty acid binding
palmitoyl-CoA oxidase activity
FAD binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors
oxidoreductase
very long-chain fatty acid metabolic process
generation of precursor metabolites and energy
lipid metabolic process
prostaglandin metabolic process
spermatogenesis
fatty acid oxidation
fatty acid beta-oxidation using acyl-CoA dehydrogenase
fatty acid beta-oxidation using acyl-CoA oxidase
alpha-linolenic acid metabolic process
fatty acid beta-oxidation
peroxisome fission
lipid homeostasis
positive regulation of cholesterol homeostasis
fatty acid metabolic process
metabolic process
oxidation-reduction process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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