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Product Details
MA5-42756
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4W3T9
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 42-321 of human ACSL4 (NP_0752661)
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2911897
Product Specific Information
Positive test controls include: 293T, HepG2, Mouse liver, Rat liver. The target is usually found in the following locations: Endoplasmic reticulum membrane, Microsome membrane, Mitochondrion outer membrane, Peroxisome membrane, Single-pass type III membrane protein.
Immunogen sequence: MAKRIKAKPT SDKPGSPYRS VTHFDSLAVI DIPGADTLDK LFDHAVSKFG KKDSLGTREI LSEENEMQPN GKVFKKLILG NYKWMNYLEV NRRVNNFGSG LTALGLKPKN TIAIFCETRA EWMIAAQTCF KYNFPLVTLY ATLGKEAVVH GLNESEASYL ITSVELLESK LKTALLDISC VKHIIYVDNK AINKAEYPEG FEIHSMQSVE ELGSNPENLG IPPSRPTPSD MAIVMYTSGS TGRPKGVMMH HSNLIAGMTG QCERIPGLGP KDTYIGYLPL
Target Information
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acyl-CoA synthetase 4; Arachidonate--CoA ligase; fatty acid Coenzyme A ligase, long chain 4; fatty acid-Coenzyme A ligase long chain 4; fatty acid-Coenzyme A ligase, long chain 4; fatty-acid-Coenzyme A ligase, long-chain 4; L MRX63; LACS 4; lignoceroyl-CoA synthase; Long-chain acyl-CoA synthetase 4; long-chain fatty-acid-Coenzyme A ligase 4; Long-chain-fatty-acid--CoA ligase 4; mACS4
Gene Aliases: 9430020A05Rik; ACS4; ACSL4; AU018108; FACL4; LACS4; MRX63; MRX68
UniProt ID: (Human) O60488, (Rat) O35547, (Mouse) Q9QUJ7
Entrez Gene ID: (Human) 2182, (Rat) 113976, (Mouse) 50790
long-chain fatty acid metabolic process
lipid metabolic process
triglyceride metabolic process
response to nutrient
fatty acid transport
long-chain fatty-acyl-CoA biosynthetic process
embryonic process involved in female pregnancy
dendritic spine development
response to interleukin-15
fatty acid metabolic process
lipid biosynthetic process
neuron differentiation
positive regulation of cell growth
negative regulation of prostaglandin secretion
metabolic process
regulation of fatty acid metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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