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Product Details
PA1-12641
Product Specifications
Species Reactivity
Chicken
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to the extracellular domain of chicken ALK2.
Conjugate
Form
Liquid
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1069974
Target Information
Activin A receptor, type I (ACVR1) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. ACVR1 signals a specific transcriptional response in concert with activin type II receptors. The ACVR1 gene encodes activin A type I receptor, which signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor type 1; activin A receptor, type I; Activin receptor type I; Activin receptor type-1; Type I TGF B receptor
Gene Aliases: ACVR1; ALK2
UniProt ID: (Chicken) Q90ZK6
Entrez Gene ID: (Chicken) 395246
protein kinase activity
protein serine/threonine kinase activity
transforming growth factor beta receptor activity, type I
protein binding
ATP binding
activin receptor activity, type I
growth factor binding
protein homodimerization activity
SMAD binding
metal ion binding
activin binding
transforming growth factor beta binding
serine/threonine protein kinase receptor
G1/S transition of mitotic cell cycle
angiogenesis
patterning of blood vessels
gastrulation with mouth forming second
mesoderm formation
neural crest cell migration
acute inflammatory response
embryonic heart tube morphogenesis
atrioventricular valve morphogenesis
mitral valve morphogenesis
endocardial cushion morphogenesis
endocardial cushion fusion
atrial septum primum morphogenesis
protein phosphorylation
transforming growth factor beta receptor signaling pathway
germ cell development
determination of left/right symmetry
gastrulation
mesoderm development
heart development
dorsal/ventral pattern formation
negative regulation of signal transduction
positive regulation of alkaline phosphatase activity
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
cell migration
peptidyl-threonine phosphorylation
regulation of ossification
positive regulation of cell migration
positive regulation of bone mineralization
BMP signaling pathway
positive regulation of BMP signaling pathway
activin receptor signaling pathway
negative regulation of activin receptor signaling pathway
intracellular signal transduction
endothelial cell activation
positive regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
mesenchymal cell differentiation
smooth muscle cell differentiation
pharyngeal system development
cardiac epithelial to mesenchymal transition
pathway-restricted SMAD protein phosphorylation
ventricular septum morphogenesis
cardiac muscle cell fate commitment
BMP signaling pathway involved in heart development
endocardial cushion cell fate commitment
cellular response to growth factor stimulus
cellular response to BMP stimulus
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of determination of dorsal identity
negative regulation of extrinsic apoptotic signaling pathway
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