Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 1
ACVR1 Antibody (PA5-142316) in WB
Western Blot analysis of ACVR1 in Human Umbilical Cord lysate (35 µg protein in RIPA buffer) using ACVR1 Polyclonal Antibody, Biotin (Product # PA5-142316) at 0.1 µg/mL incubated for 1 hour. Detected by chemiluminescence, using streptavidin-HRP and using NAP blocker as a substitute for skimmed milk.
Product Details
PA5-142316
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-RKFKRRNQERLNPRD.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2932967
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Activin A receptor, type I (ACVR1) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. ACVR1 signals a specific transcriptional response in concert with activin type II receptors. The ACVR1 gene encodes activin A type I receptor, which signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: activin A receptor type I; activin A receptor, type I; activin A receptor, type II-like kinase 2; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; ACTR-I; ALK-2; hydroxyalkyl-protein kinase; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I
Gene Aliases: ACTRI; ACVR1; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI
UniProt ID: (Human) Q04771
Entrez Gene ID: (Human) 90
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta receptor activity, type I
protein binding
ATP binding
activin receptor activity, type I
peptide hormone binding
protein homodimerization activity
SMAD binding
metal ion binding
activin binding
transforming growth factor beta binding
serine/threonine protein kinase receptor
G1/S transition of mitotic cell cycle
patterning of blood vessels
in utero embryonic development
gastrulation with mouth forming second
mesoderm formation
neural crest cell migration
acute inflammatory response
embryonic heart tube morphogenesis
outflow tract septum morphogenesis
atrioventricular valve morphogenesis
mitral valve morphogenesis
endocardial cushion morphogenesis
endocardial cushion fusion
atrial septum primum morphogenesis
protein phosphorylation
transforming growth factor beta receptor signaling pathway
germ cell development
determination of left/right symmetry
negative regulation of signal transduction
positive regulation of pathway-restricted SMAD protein phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
regulation of ossification
positive regulation of cell migration
positive regulation of bone mineralization
BMP signaling pathway
activin receptor signaling pathway
negative regulation of activin receptor signaling pathway
positive regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
smooth muscle cell differentiation
pharyngeal system development
pathway-restricted SMAD protein phosphorylation
ventricular septum morphogenesis
cardiac muscle cell fate commitment
BMP signaling pathway involved in heart development
endocardial cushion cell fate commitment
cellular response to glucocorticoid stimulus
cellular response to BMP stimulus
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of determination of dorsal identity
negative regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support