Invitrogen

ACVR1 Polyclonal Antibody

View all (21) ACVR1 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-28662

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fragment corresponding to a region within amino acids 214 and 509 of Human Activin A receptor type I
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.9 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 1% BSA, 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2546138

Product Specific Information

Recommended positive controls: mouse heart, rat liver.

Predicted reactivity: Mouse (99%), Rat (99%), Xenopus laevis (93%), Rhesus Monkey (100%), Bovine (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Activin A receptor, type I (ACVR1) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. ACVR1 signals a specific transcriptional response in concert with activin type II receptors. The ACVR1 gene encodes activin A type I receptor, which signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activin A receptor type I; activin A receptor, type 1; activin A receptor, type I; activin A receptor, type II-like kinase 2; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; activin type I receptor; ACTR-I; ALK-2; ALK2-B; hydroxyalkyl-protein kinase; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSK-7L; TSR-I

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Gene Aliases: ActR-I; ACTRI; ActRIA; Acvr; ACVR1; ACVR1A; ACVRLK2; Alk-2; ALK2; Alk8; D330013D15Rik; FOP; SKR1; Tgfb1; Tsk7L; TSRI

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UniProt ID: (Human) Q04771, (Rat) P80201, (Mouse) P37172

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Entrez Gene ID: (Human) 90, (Rat) 79558, (Mouse) 11477

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Function(s)
protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity transforming growth factor beta receptor activity, type I protein binding ATP binding activin receptor activity, type I peptide hormone binding protein homodimerization activity SMAD binding metal ion binding activin binding transforming growth factor beta binding growth factor binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
Process(es)
G1/S transition of mitotic cell cycle patterning of blood vessels in utero embryonic development gastrulation with mouth forming second mesoderm formation neural crest cell migration acute inflammatory response embryonic heart tube morphogenesis outflow tract septum morphogenesis atrioventricular valve morphogenesis mitral valve morphogenesis endocardial cushion morphogenesis endocardial cushion fusion atrial septum primum morphogenesis protein phosphorylation transforming growth factor beta receptor signaling pathway germ cell development determination of left/right symmetry negative regulation of signal transduction positive regulation of pathway-restricted SMAD protein phosphorylation peptidyl-threonine phosphorylation signal transduction by protein phosphorylation regulation of ossification positive regulation of cell migration positive regulation of bone mineralization BMP signaling pathway activin receptor signaling pathway negative regulation of activin receptor signaling pathway positive regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter smooth muscle cell differentiation pharyngeal system development pathway-restricted SMAD protein phosphorylation ventricular septum morphogenesis cardiac muscle cell fate commitment BMP signaling pathway involved in heart development endocardial cushion cell fate commitment cellular response to glucocorticoid stimulus cellular response to BMP stimulus positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of determination of dorsal identity negative regulation of extrinsic apoptotic signaling pathway urogenital system development gastrulation mesoderm development heart development regulation of skeletal muscle tissue development transmembrane receptor protein serine/threonine kinase signaling pathway embryo development phosphorylation intracellular signal transduction
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