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Product Details
PA5-33317
Product Specifications
Species Reactivity
Bat,
Bovine,
Human,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 16 amino acid peptide from internal region of human ACVR1C.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2550701
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Bovine, Bat, Pig (100%); Marmoset, Elephant, Panda, Horse, Rabbit (94%); Opossum, Turkey, Chicken, Platypus (88%).
Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.
Target Information
ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor type IC; activin A receptor, type IC; Activin receptor type IC; Activin receptor type-1C; Activin receptor-like kinase 7; ACTR-IC; ACTRI; ACVR1A; ACVR1C; ACVRLK2; ALK-7; ALK2; FOP; TSRI
Gene Aliases: ACVR1C; ACVRLK7; ALK7
UniProt ID: (Human) Q8NER5
Entrez Gene ID: (Pig) 100156756, (Human) 130399, (Bovine) 536380
response to dietary excess
protein phosphorylation
response to glucose
lipid storage
signal transduction by protein phosphorylation
cell differentiation
apoptotic nuclear changes
response to insulin
nodal signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of insulin secretion
negative regulation of trophoblast cell migration
negative regulation of chorionic trophoblast cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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