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ACVR1C Antibody (PA5-87475) in IHC (P)
Immunohistochemistry analysis of ACVR1C in paraffin-embedded mouse stomach. Samples were incubated with ACVR1C Polyclonal antibody (Product # PA5-87475) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-87475
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 22-113 of human ACVR1C (NP_6603022)
Conjugate
Form
Liquid
Concentration
0.67 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804181
Product Specific Information
Immunogen sequence: LSPGLKCVCL LCDSSNFTCQ TEGACWASVM LTNGKEQVIK SCVSLPELNA QVFCHSSNNV TKTECCFTDF CNNITLHLPT ASPNAPKLGP ME; Positive Samples: SH-SY5Y; Cellular Location: Membrane, Single-pass type I membrane protein
Target Information
ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor type IC; activin A receptor, type IC; Activin receptor type IC; Activin receptor type-1C; Activin receptor-like kinase 7; ACTR-IC; ACTRI; ACVR1A; ACVR1C; acvr1c {ECO:0000312|EMBL:AAC52803.1}; ACVRLK2; ALK-7; ALK2; FOP; TGF-beta type 1 receptor; TSRI
Gene Aliases: ACVR1C; ACVRLK7; Alk-7; ALK7; C230097P10; habrec1
UniProt ID: (Human) Q8NER5, (Rat) P70539, (Mouse) Q8K348
Entrez Gene ID: (Human) 130399, (Rat) 245921, (Mouse) 269275
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
ATP binding
activin receptor activity, type I
growth factor binding
nodal binding
metal ion binding
transforming growth factor beta-activated receptor activity
SMAD binding
activin binding
BMP receptor binding
nucleotide binding
protein kinase activity
transmembrane receptor protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
serine/threonine protein kinase receptor
response to dietary excess
protein phosphorylation
response to glucose
lipid storage
signal transduction by protein phosphorylation
cell differentiation
apoptotic nuclear changes
response to insulin
nodal signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of insulin secretion
negative regulation of trophoblast cell migration
negative regulation of chorionic trophoblast cell proliferation
ovarian follicle development
in utero embryonic development
apoptotic process
transforming growth factor beta receptor complex assembly
determination of left/right symmetry
response to organic cyclic compound
cerebellum development
hippocampus development
midbrain development
activin receptor signaling pathway
response to lipid
response to drug
regulation of apoptotic process
trophectodermal cell proliferation
transmembrane receptor protein serine/threonine kinase signaling pathway
phosphorylation
positive regulation of apoptotic process
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