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Product Details
MA5-23803
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
118311
Immunogen
Mouse myeloma cell line NS0-derived recombinant rat ALK-7 Leu26-Arg108
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608289
Product Specific Information
In Western blots, no cross-reactivity with recombinant human Activin R1B is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activin receptor type IC; Activin receptor type-1C; Activin receptor-like kinase 7; ACTR-IC; ACTRI; ACVR1A; acvr1c {ECO:0000312|EMBL:AAC52803.1}; ACVRLK2; ALK-7; ALK2; FOP; TGF-beta type 1 receptor; TSRI
Gene Aliases: Acvr1c; Alk-7; Alk7; habrec1
UniProt ID: (Rat) P70539
Entrez Gene ID: (Rat) 245921
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
ATP binding
activin receptor activity, type I
growth factor binding
nodal binding
SMAD binding
metal ion binding
activin binding
BMP receptor binding
serine/threonine protein kinase receptor
ovarian follicle development
in utero embryonic development
response to dietary excess
protein phosphorylation
apoptotic process
transforming growth factor beta receptor complex assembly
determination of left/right symmetry
response to glucose
response to organic cyclic compound
lipid storage
cerebellum development
hippocampus development
signal transduction by protein phosphorylation
cell differentiation
apoptotic nuclear changes
midbrain development
response to insulin
activin receptor signaling pathway
response to lipid
nodal signaling pathway
response to drug
regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of insulin secretion
negative regulation of trophoblast cell migration
negative regulation of chorionic trophoblast cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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