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ACVR2A Antibody (PA5-119790) in WB
Western blot analysis of ACVR2A on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. ACVR2A Polyclonal Antibody (Product # PA5-119790) at 1:500 was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody at 1:200,000 dilution was used for 1 hour at room temperature. Positive control: Lane 1: SW480 cell lysate. Lane 2: K562 cell lysate. Lane 3: HepG2 cell lysate. Lane 4: Mouse kidney tissue lysate.
Product Details
PA5-119790
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within human ACVR2A aa 470-513
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2913362
Product Specific Information
Positive Control: SW480 cell lysate, K562 cell lysate, HepG2 cell lysate, mouse kidney tissue lysate, mouse testis tissue lysate, rat testis tissue lysate.
Subcellular Location: Membrane.
Target Information
Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases. ACVR2A is involved in the activin and myostatin signaling pathway. (ACVR2A Aliases: ACVR2, ACTRII). These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor type IIA; activin A receptor, type IIA; activin receptor IIA; Activin receptor type IIA; Activin receptor type-2A; ACTR-IIA; type II activin receptor
Gene Aliases: ACTRII; ActrIIa; ACVR2; ACVR2A; rActR-II; TactrII
UniProt ID: (Human) P27037, (Rat) P38444, (Mouse) P27038
Entrez Gene ID: (Human) 92, (Rat) 29263, (Mouse) 11480
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
coreceptor activity
activin-activated receptor activity
growth factor binding
PDZ domain binding
inhibin binding
protein self-association
metal ion binding
activin binding
BMP receptor activity
transforming growth factor beta-activated receptor activity
activin receptor activity, type II
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
serine/threonine protein kinase receptor
gastrulation with mouth forming second
positive regulation of protein phosphorylation
transmembrane receptor protein serine/threonine kinase signaling pathway
spermatogenesis
determination of left/right symmetry
mesoderm development
anterior/posterior pattern specification
positive regulation of pathway-restricted SMAD protein phosphorylation
signal transduction by protein phosphorylation
positive regulation of bone mineralization
BMP signaling pathway
regulation of BMP signaling pathway
activin receptor signaling pathway
positive regulation of activin receptor signaling pathway
sperm ejaculation
penile erection
positive regulation of erythrocyte differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
embryonic skeletal system development
regulation of nitric-oxide synthase activity
Sertoli cell proliferation
cellular response to BMP stimulus
protein phosphorylation
male gonad development
regulation of signal transduction
response to organic substance
positive regulation of follicle-stimulating hormone secretion
phosphorylation
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