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Product Details
MA5-30037
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
037
Immunogen
Recombinant Human ACVR2B Protein (Met1-Thr134)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2785828
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human ACVR2B.
Target Information
ACVR2B is a type II member of the TGF-beta family of receptor ser/thr kinases and is involved in the activin and myostatin signaling pathway. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-beta forms. To date, seven type I and five type II activin receptors have been cloned from mammals, including activin receptor IA, activin receptor IIA, activin receptor IB, and activin receptor IIB. In addition, two splice variants of activin receptor IIA and five splice variants of activin receptor IIB have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor type IIB; activin A receptor, type IIB; Activin receptor type IIB; Activin receptor type-2B; ACTR-IIB; MGC116908
Gene Aliases: ActR-IIB; ACTRIIB; ACVR2B; HTX4
UniProt ID: (Human) Q13705
Entrez Gene ID: (Human) 93
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
activin receptor activity, type II
growth factor binding
inhibin binding
metal ion binding
activin binding
serine/threonine protein kinase receptor
negative regulation of transcription from RNA polymerase II promoter
gastrulation with mouth forming second
kidney development
lymphangiogenesis
blood vessel remodeling
regulation of transcription, DNA-templated
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway
determination of left/right symmetry
mesoderm development
heart development
response to glucose
post-embryonic development
anterior/posterior pattern specification
signal transduction by protein phosphorylation
insulin secretion
lung development
positive regulation of bone mineralization
BMP signaling pathway
pancreas development
activation of protein kinase activity
activin receptor signaling pathway
positive regulation of activin receptor signaling pathway
organ growth
odontogenesis of dentin-containing tooth
positive regulation of osteoblast differentiation
embryonic foregut morphogenesis
skeletal system morphogenesis
palate development
lymphatic endothelial cell differentiation
artery development
venous blood vessel development
retina vasculature development in camera-type eye
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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