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Product Details
66620-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2A6B7
Immunogen
ADAM10 Fusion Protein Ag23062 (306-512 aa encoded by BC126253)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EQNHDDYCL AYVFTDRDFD DGVLGLAWVG APSGSSGGIC EKSKLYSDGK KKSLNTGIIT VQNYGSHVPP KVSHITFAHE VGHNFGSPHD SGTECTPGES KNLGQKENGN YIMYARATSG DKLNNNKFSL CSIRNISQVL EKKRNNCFVE SGQPICGNGM VEQGEECDCG YSDQCKDECC FDANQPEGRK CKLKPGKQCS TVCIQVKV (306-512 aa encoded by BC126253)
Target Information
Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase; ADAM; ADAM 10; ADAMs; CD156c; CDw156; Disintegrin and metalloproteinase domain-containing protein 10; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; metalloendopeptidases
Gene Aliases: AD10; AD18; ADAM10; CD156c; CDw156; HsT18717; KUZ; MADM; RAK
UniProt ID: (Human) O14672
Entrez Gene ID: (Human) 102
in utero embryonic development
protein phosphorylation
membrane protein ectodomain proteolysis
negative regulation of cell adhesion
Notch signaling pathway
Notch receptor processing
integrin-mediated signaling pathway
cell-cell signaling
positive regulation of cell proliferation
positive regulation of T cell chemotaxis
protein processing
extracellular matrix disassembly
positive regulation of cell growth
positive regulation of cell migration
response to tumor necrosis factor
monocyte activation
ephrin receptor signaling pathway
PMA-inducible membrane protein ectodomain proteolysis
constitutive protein ectodomain proteolysis
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