Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-27459
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 255 of Human ADAM15
Conjugate
Form
Liquid
Concentration
0.347 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2544935
Product Specific Information
Recommended positive controls: HeLa, HepG2, Molt-4, NIH-3T3.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: a disintegrin and metallopeptidase domain 15 (metargidin); a disintegrin and metalloprotease domain 15 (metargidin); a disintegrin and metalloproteinase; a disintegrin and metalloproteinase domain 15 (metargidin); AD56; ADAM; ADAM 15; ADAMs; CRII-7; disintegrin and metalloprotease 15; Disintegrin and metalloproteinase domain-containing protein 15; MDC-15; metalloendopeptidases; Metalloprotease RGD disintegrin protein; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; Metargidin; tMDC VI
Gene Aliases: ADAM15; MDC15; metargidin; tMDCVI
UniProt ID: (Human) Q13444, (Rat) Q9QYV0, (Mouse) O88839
Entrez Gene ID: (Human) 8751, (Rat) 57025, (Mouse) 11490
angiogenesis
negative regulation of cell-matrix adhesion
proteolysis
apoptotic process
cell-matrix adhesion
integrin-mediated signaling pathway
male gonad development
extracellular matrix disassembly
negative regulation of cell growth
negative regulation of cell migration
collagen catabolic process
tissue regeneration
innate immune response
cardiac epithelial to mesenchymal transition
protein kinase C signaling
negative regulation of receptor binding
single organismal cell-cell adhesion
cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support