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ADAM15 Antibody (MA5-28999) in Flow
Flow cytometric analysis of human ADAM15 expression on HeLa cells. Cells were stained with ADAM15 Monoclonal Antibody (1B7G8) (Product # MA5-28999), then a FITC-conjugated Secondary antibody. The histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Product Details
MA5-28999
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B7G8
Immunogen
Recombinant Human ADAM15 protein (Met1-Thr696)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2784939
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human ADAM15.
Target Information
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metalloproteinase; a disintegrin and metalloproteinase domain 15 (metargidin); ADAM; ADAM 15; ADAMs; Disintegrin and metalloproteinase domain-containing protein 15; MDC-15; metalloendopeptidases; Metalloprotease RGD disintegrin protein; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; Metargidin
Gene Aliases: ADAM15; MDC15
UniProt ID: (Human) Q13444
Entrez Gene ID: (Human) 8751
angiogenesis
negative regulation of cell-matrix adhesion
proteolysis
apoptotic process
cell-matrix adhesion
integrin-mediated signaling pathway
male gonad development
extracellular matrix disassembly
negative regulation of cell growth
negative regulation of cell migration
collagen catabolic process
tissue regeneration
innate immune response
cardiac epithelial to mesenchymal transition
protein kinase C signaling
negative regulation of receptor binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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