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ADAM15 Antibody (MA5-35694) in IHC (P)
Immunohistochemistry analysis of ADAM15 in paraffin-embedded human liver. Samples were incubated with ADAM15 Monoclonal antibody (Product # MA5-35694) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Product Details
MA5-35694
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC1419
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ADAM15 (Q13444)
Conjugate
Form
Liquid
Concentration
3 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2849594
Product Specific Information
Immunogen sequence: RHIRRRRDVV TETKTVELVI VADHSEAQKY RDFQHLLNRT LEVALLLDTF FRPLNVRVAL VGLEAWTQRD LVEISPNPAV TLENFLHWRR AHLLPRLPHD S
Target Information
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metallopeptidase domain 15 (metargidin); a disintegrin and metalloprotease domain 15 (metargidin); a disintegrin and metalloproteinase; a disintegrin and metalloproteinase domain 15 (metargidin); AD56; ADAM; ADAM 15; ADAMs; CRII-7; disintegrin and metalloprotease 15; Disintegrin and metalloproteinase domain-containing protein 15; MDC-15; metalloendopeptidases; Metalloprotease RGD disintegrin protein; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; Metargidin; tMDC VI
Gene Aliases: ADAM15; MDC15; metargidin; tMDCVI
UniProt ID: (Human) Q13444, (Rat) Q9QYV0, (Mouse) O88839
Entrez Gene ID: (Human) 8751, (Rat) 57025, (Mouse) 11490
angiogenesis
negative regulation of cell-matrix adhesion
proteolysis
apoptotic process
cell-matrix adhesion
integrin-mediated signaling pathway
male gonad development
extracellular matrix disassembly
negative regulation of cell growth
negative regulation of cell migration
collagen catabolic process
tissue regeneration
innate immune response
cardiac epithelial to mesenchymal transition
protein kinase C signaling
negative regulation of receptor binding
single organismal cell-cell adhesion
cell adhesion
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