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Immunogen sequence: ARKQLKKWFA KEEEFPSSES KSEGSTQTYA SQSSSEGSTQ TYASQTRSES SSQADTSKSK SEDSAEAYTS RSKSQDSTQT QSSSN; Positive Samples: HeLa, 293T, Mouse brain; Cellular Location: Membrane, Single-pass type I membrane protein
This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the testis. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
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Protein Aliases: a disintegrin and metalloprotease domain 32; a disintegrin and metalloproteinase; a disintegrin and metalloproteinase domain 32; ADAM; ADAM 32; ADAMs; Disintegrin and metalloproteinase domain-containing protein 32; FLJ26299; FLJ29004; metalloendopeptidases; metalloproteinase 12-like protein; testicular tissue protein Li 13
Gene Aliases: ADAM32; UNQ5982/PRO21340
UniProt ID: (Human) Q8TC27, (Mouse) Q8K410
Entrez Gene ID: (Human) 203102, (Mouse) 353188
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