Proteintech

ADAM8 Polyclonal Antibody

ADAM8 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ADAM8 Antibody (23778-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 23778-1-AP ( ADAM8 Antibody) at dilution of 1:50 (under 40x lens).

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Product Details

23778-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ADAM8 Fusion Protein Ag17262 (145-494 aa encoded by BC115404)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.42 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to ADAM8.

Immunogen sequence: EGGEGGRHA VYQAEHLLQT AGTCGVSDDS LGSLLGPRTA AVFRPRPGDS LPSRETRYVE LYVVVDNAEF QMLGSEAAVR HRVLEVVNHV DKLYQKLNFR VVLVGLEIWN SQDRFHVSPD PSVTLENLLT WQARQRTRRH LHDNVQLITG VDFTGTTVGF ARVSAMCSHS SGAVNQDHSK NPVGVACTMA HEMGHNLGMD HDENVQGCRC QERFEAGRCI MAGSIGSSFP RMFSDCSQAY LESFLERPQS VCLANAPDLS HLVGGPVCGN LFVERGEQCD CGPPEDCRNR CCNSTTCQLA EGAQCAHGTC CQECKVKPAG ELCRPKKDMC DLEEFCDGRH PECPEDAFQE N (145-494 aa encoded by BC115404)

Target Information

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The GBM Tumor Microenvironment as a Modulator of Therapy Response: ADAM8 Causes Tumor Infiltration of Tams through HB-EGF/EGFR-Mediated CCL2 Expression and Overcomes TMZ Chemosensitization in Glioblastoma.

Cancers

Liu X,Huang Y,Qi Y,Wu S,Hu F,Wang J,Shu K,Zhang H,Bartsch JW,Nimsky C,Dong F,Lei T

Fri Oct 07 00:00:00 EDT 2022

Cancers

Liu X,Huang Y,Qi Y,Wu S,Hu F,Wang J,Shu K,Zhang H,Bartsch JW,Nimsky C,Dong F,Lei T

Fri Oct 07 00:00:00 EDT 2022

Cancers

Liu X,Huang Y,Qi Y,Wu S,Hu F,Wang J,Shu K,Zhang H,Bartsch JW,Nimsky C,Dong F,Lei T

Fri Oct 07 00:00:00 EDT 2022

Cancers

Liu X,Huang Y,Qi Y,Wu S,Hu F,Wang J,Shu K,Zhang H,Bartsch JW,Nimsky C,Dong F,Lei T

Fri Oct 07 00:00:00 EDT 2022

Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction.

Nature communications

Klapproth E,Witt A,Klose P,Wiedemann J,Vavilthota N,Künzel SR,Kämmerer S,Günscht M,Sprott D,Lesche M,Rost F,Dahl A,Rauch E,Kattner L,Weber S,Mirtschink P,Kopaliani I,Guan K,Lorenz K,Saftig P,Wagner M,El-Armouche A

Sat Dec 10 00:00:00 EST 2022

Suppression of ADAM8 attenuates angiotensin II-induced cardiac fibrosis and endothelial-mesenchymal transition via inhibiting TGF-β1/Smad2/Smad3 pathways.

Experimental animals

Yao L,Shao W,Chen Y,Wang S,Huang D

Wed Feb 09 00:00:00 EST 2022

Suppression of ADAM8 attenuates angiotensin II-induced cardiac fibrosis and endothelial-mesenchymal transition via inhibiting TGF-β1/Smad2/Smad3 pathways.

Experimental animals

Yao L,Shao W,Chen Y,Wang S,Huang D

Wed Feb 09 00:00:00 EST 2022

ADAM8 Activates NLRP3 Inflammasome to Promote Cerebral Ischemia-Reperfusion Injury.

Journal of healthcare engineering

Lu H,Meng Y,Han X,Zhang W

Fri Jan 07 00:00:00 EST 2022

ADAM8 Activates NLRP3 Inflammasome to Promote Cerebral Ischemia-Reperfusion Injury.

Journal of healthcare engineering

Lu H,Meng Y,Han X,Zhang W

Fri Jan 07 00:00:00 EST 2022

Matrix metalloprotease-mediated cleavage of neural glial-related cell adhesion molecules activates quiescent olfactory stem cells via EGFR.

Molecular and cellular neurosciences

Chen ZH,Luo XC,Yu CR,Huang L

Thu Oct 01 00:00:00 EDT 2020

Translation control of the immune checkpoint in cancer and its therapeutic targeting.

Nature medicine

Xu Y,Poggio M,Jin HY,Shi Z,Forester CM,Wang Y,Stumpf CR,Xue L,Devericks E,So L,Nguyen HG,Griselin A,Gordan JD,Umetsu SE,Reich SH,Worland ST,Asthana S,Barna M,Webster KR,Cunningham JT,Ruggero D

Fri Feb 01 00:00:00 EST 2019

Translation control of the immune checkpoint in cancer and its therapeutic targeting.

Nature medicine

Xu Y,Poggio M,Jin HY,Shi Z,Forester CM,Wang Y,Stumpf CR,Xue L,Devericks E,So L,Nguyen HG,Griselin A,Gordan JD,Umetsu SE,Reich SH,Worland ST,Asthana S,Barna M,Webster KR,Cunningham JT,Ruggero D

Fri Feb 01 00:00:00 EST 2019

ADAM17 promotes lymph node metastasis in gastric cancer via activation of the Notch and Wnt signaling pathways.

International journal of molecular medicine

Li W,Wang D,Sun X,Zhang Y,Wang L,Suo J

Fri Feb 01 00:00:00 EST 2019

ADAM17 promotes lymph node metastasis in gastric cancer via activation of the Notch and Wnt signaling pathways.

International journal of molecular medicine

Li W,Wang D,Sun X,Zhang Y,Wang L,Suo J

Fri Feb 01 00:00:00 EST 2019

ADAM17 promotes lymph node metastasis in gastric cancer via activation of the Notch and Wnt signaling pathways.

International journal of molecular medicine

Li W,Wang D,Sun X,Zhang Y,Wang L,Suo J

Fri Feb 01 00:00:00 EST 2019

ADAM17 promotes lymph node metastasis in gastric cancer via activation of the Notch and Wnt signaling pathways.

International journal of molecular medicine

Li W,Wang D,Sun X,Zhang Y,Wang L,Suo J

Fri Feb 01 00:00:00 EST 2019

High ADAM8 expression is associated with poor prognosis in patients with hepatocellular carcinoma.

Pathology oncology research : POR

Zhang Y,Tan YF,Jiang C,Zhang K,Zha TZ,Zhang M

Tue Jan 01 00:00:00 EST 2013

High ADAM8 expression is associated with poor prognosis in patients with hepatocellular carcinoma.

Pathology oncology research : POR

Zhang Y,Tan YF,Jiang C,Zhang K,Zha TZ,Zhang M

Tue Jan 01 00:00:00 EST 2013

Bioinformatics

Protein Aliases: a disintegrin and metalloproteinase; a disintegrin and metalloproteinase domain 8; ADAM; ADAM 8; ADAMs; CD156a; Cell surface antigen MS2; Disintegrin and metalloproteinase domain-containing protein 8; human leukocyte differentiation antigen; Macrophage cysteine-rich glycoprotein; metalloendopeptidases; MGC134985

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Gene Aliases: ADAM 8; ADAM8; CD156; CD156a; E430039A18Rik; MS2

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UniProt ID: (Human) P78325, (Mouse) Q05910

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Entrez Gene ID: (Human) 101, (Mouse) 11501

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Function(s)

metalloendopeptidase activity serine-type endopeptidase activity calcium ion binding protein binding metallopeptidase activity zinc ion binding protein self-association cell adhesion molecule binding metalloprotease

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ADAM8 Polyclonal Antibody

ADAM8 Antibody (23778-1-AP) in IHC (P)

Product Details

23778-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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