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ADAMTS1 Antibody (PA5-47790) in IHC (F)
Immunohistochemical analysis of ADAMTS1 in immersion fixed frozen sections of mouse embryo (13 d.p.c.). Samples were incubated in ADAMTS1 polyclonal antibody (Product # PA5-47790) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cartilage primordium... View More
Product Details
PA5-47790
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHO-derived recombinant mouse ADAMTS1 Phe254-Cys725
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2576699
Product Specific Information
In direct ELISAs, less than 5% cross-reactivity with recombinant human (rh) ADAMTS4 and rhADAMTS15 is observed and less than 1% cross-reactivity with rhADAMTSL1.2, rhADAMTSL2, rhADAMTS5, rhADAMTS8, rhADAMTS10, rhADAMTS12, rhADAMTS13, and rhADAMTS16 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
ADAMTS-1 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1; ADAM; ADAM metallopeptidase with thrombospondin type 1 motif, 1; ADAM-TS 1; ADAM-TS1; ADAMs; ADAMTS-1; human metalloproteinase with thrombospondin type 1 motifs; metalloendopeptidases; METH-1
Gene Aliases: ADAM-TS1; ADAMTS; ADAMTS-1; ADAMTS1; C3-C5; KIAA1346; METH-1; METH1
UniProt ID: (Human) Q9UHI8, (Mouse) P97857
Entrez Gene ID: (Human) 9510, (Mouse) 11504
ovulation from ovarian follicle
kidney development
proteolysis
integrin-mediated signaling pathway
negative regulation of cell proliferation
positive regulation of neuron projection development
tooth eruption
heart trabecula formation
cellular response to vitamin D
cellular response to parathyroid hormone stimulus
cellular response to prostaglandin E stimulus
negative regulation of angiogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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