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Product Details
PA5-57489
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ADAMTS12. Recombinant protein control fragment (Product #RP-102430).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2637662
Product Specific Information
Immunogen sequence: SSDTGPTSEG GLVATTTSGS GLSSSRNPIT WPVTPFYNTL TKGPEMEIHS GSGEEREQPE DKDESNPVIW TKIRVPGNDA PVESTEMPLA PPLTPDLSRE SWWPPFSTVM EGLLPSQRPT TSETGTPRVE GMVTEKPANT LLPL
Highest antigen sequence identity to the following orthologs: Mouse - 57%, Rat - 57%.
Target Information
This protein is a disintegrin and metalloproteinase with thrombospondin motifs-12 (ADAMTS12), which is a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 12; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; ADAM; ADAM metallopeptidase with thrombospondin type 1 motif, 12; ADAM-TS 12; ADAM-TS12; ADAMs; ADAMTS-12; metalloendopeptidases; UNQ1918
Gene Aliases: ADAMTS12; PRO4389; UNQ1918/PRO4389
UniProt ID: (Human) P58397
Entrez Gene ID: (Human) 81792
cell-matrix adhesion
cell migration
proteoglycan catabolic process
negative regulation of chondrocyte differentiation
regulation of inflammatory response
proteolysis involved in cellular protein catabolic process
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to BMP stimulus
regulation of endothelial tube morphogenesis
negative regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of cellular response to vascular endothelial growth factor stimulus
negative regulation of cellular response to hepatocyte growth factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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