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ADAMTS13 Antibody (A301-000A) in IP
Detection of human ADAMTS13 by western blot and immunoprecipitation. Samples: Pooled normal human serum (300 µl/IP, 20% of IP loaded; 1.5 µl for input). Antibodies: Agarose immobilized goat anti-ADAMTS13 antibodies S300-391, S301-000, S301-001, S301-002 and S301-003 were used at the equivalent of 35 µg of antibody per IP. For blotting immunoprecipitated ADAMTS13, goat anti-ADAMTS13 antibody A300-002A was used at 1 µg/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. Note: The anti-ADAMTS13 an... View More
Product Details
A301-000A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 75 and 125 of human ADAM (a disintegrin-like and metalloprotease) metallopeptidase with thrombospondin type 1 motif, 13.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Gorilla and Chimpanzee
Target Information
ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 13; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13; ADAM; ADAM metallopeptidase with thrombospondin type 1 motif, 13; ADAM-TS 13; ADAMs; metalloendopeptidases; von Willebrand factor-cleaving protease; vWF-cleaving protease; vWF-CP
Gene Aliases: ADAM-TS13; ADAMTS-13; ADAMTS13; C9orf8; UNQ6102/PRO20085; vWF-CP; VWFCP
UniProt ID: (Human) Q76LX8
Entrez Gene ID: (Human) 11093
proteolysis
cell-matrix adhesion
integrin-mediated signaling pathway
glycoprotein metabolic process
response to toxic substance
protein processing
platelet activation
response to interferon-gamma
response to tumor necrosis factor
protein O-linked fucosylation
peptide catabolic process
response to interleukin-4
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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