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Invitrogen
ADAMTS13 Recombinant Rabbit Monoclonal Antibody (7B2Z8)
Product Details
MA5-42805
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
7B2Z8
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ADAMTS13 (Q76LX8).
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2911946
Product Specific Information
Positive test controls include: Mouse liver, Mouse spleen, Mouse plasma, Rat plasma.
Immunogen sequence: LSPGAPLKGR PPSPGFQRQR QRQRRAAGGI LHLELLVAVG PDVFQAHQED TERYVLTNLN IGAELLRDPS LGAQFRVHLV KMVILTEPEG APNITANLTS S
Target Information
ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 13; A disintegrin and metalloproteinase with thrombospondin motifs 13-like; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13; ADAM; ADAM metallopeptidase with thrombospondin type 1 motif, 13; ADAM-TS 13; ADAMs; metalloendopeptidases; von Willebrand factor-cleaving protease; vWF-cleaving protease; vWF-CP; vWF-CP mRNA for von Willebrand factor-cleaving
Gene Aliases: ADAM-TS13; ADAMTS-13; ADAMTS13; C9orf8; Gm710; UNQ6102/PRO20085; vWF-CP; VWFCP
UniProt ID: (Human) Q76LX8, (Mouse) Q769J6
Entrez Gene ID: (Human) 11093, (Mouse) 279028, (Rat) 102554393
proteolysis
cell-matrix adhesion
integrin-mediated signaling pathway
glycoprotein metabolic process
response to toxic substance
protein processing
platelet activation
response to interferon-gamma
response to tumor necrosis factor
protein O-linked fucosylation
peptide catabolic process
response to interleukin-4
blood coagulation
hemostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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