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Invitrogen
ADAMTS4 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
Product Details
PA1-1750
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Pig
Published species
Bovine,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues C Y(590) N H R T D L F K S F P G P(603) of human ADAMTS4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_325011
Product Specific Information
PA1-1750 detects ADAMTS4 from porcine, bovine, and human samples. PA1-1750 is specific for ADAMTS4 and shows no cross-reactivity with other ADAMTS family members.
PA1-1750 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~68 and an~53 kDa protein representing ADAMTS4 from human recombinant ADAMTS4. Depending on the extent of C-terminal processing, several smaller bands may also be seen using this antibody.
PA1-1750 immunogen is a Synthetic peptide corresponding to residues C Y(590) N H R T D L F K S F P G P(603) of human ADAMTS4. This polyclonal antibody has been referred to as: JSCYNH.
Target Information
This gene encodes a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 4; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; ADAM; ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADAM-TS 4; ADAM-TS4; ADAMs; ADAMTS family member; ADAMTS-4; ADMP-1; Aggrecanase 1; Aggrecanase-1; metalloendopeptidases; metalloproteinase
Gene Aliases: ADAMTS-2; ADAMTS-4; ADAMTS4; ADMP-1; KIAA0688; UNQ769/PRO1563
UniProt ID: (Bovine) Q9TT93, (Human) O75173
Entrez Gene ID: (Bovine) 286806, (Human) 9507, (Pig) 100157276
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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