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Product Details
PA5-60972
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ADAMTS7. Recombinant protein control fragment (Product #RP-102975).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2637671
Product Specific Information
Immunogen sequence: LGRAHIRAHT PACHLLGEVQ DSELEGGLAA ISACDGLKGV FLLSN
Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 71%.
Target Information
ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an N-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a C-terminus that contains a varying number of thrombospondin type-1 (TSP-1) motifs. ADAMTS genes are primarily expressed in fetal tissues, including lung, kidney and liver. ADAMTS-7 (ADAM metallopeptidase with thrombospondin type 1 motif, 7), also known as COMPase, is a 1,686 amino acid protein that exists as two alternatively spliced isoforms. Encoded by a gene that maps to human chromosome 15q25.1, ADAMTS-7 contains eight TSP-1 motifs and binds one zinc ion per subunit. ADAMTS-7 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. ADAMTS-7 is also located in meniscus, bone, tendon, cartilage, synovium, fat and ligaments, and is up-regulated in articular cartilage and synovium in arthritis patients. ADAMTS-7 functions as a metalloprotease and may play a role in the degradation of COMP. ADAMTS-7 is pH dependent, with optimum pH between 7.5 and 9.5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metalloprotease with thrombospondin motifs-7 preproprotein; a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 7; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7; ADAM; ADAM-TS 7; ADAMs; COMPase; metalloendopeptidases
Gene Aliases: ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7
UniProt ID: (Human) Q9UKP4
Entrez Gene ID: (Human) 11173
negative regulation of chondrocyte differentiation
protein O-linked fucosylation
proteolysis involved in cellular protein catabolic process
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to BMP stimulus
mitophagy in response to mitochondrial depolarization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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