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Product Details
PA5-31751
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 121 and 359 of Human ADC
Conjugate
Form
Liquid
Concentration
1.02 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2549224
Product Specific Information
Recommended positive controls: SK-N-SH, human normal cerebellar.
Predicted reactivity: Mouse (85%), Rat (86%), Dog (88%), Cat (88%), Pig (89%), Rabbit (90%), Sheep (86%), Rhesus Monkey (96%), Bovine (86%), Guinea pig (85%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is an enzyme that in humans is encoded by the AZIN2 gene. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADC; Antizyme inhibitor 2; ARGDC; Arginine decarboxylase; AzI2; ODC antizyme inhibitor-2; ODC-like protein; ODC-p; ODC-paralogue; ornithine decarboxylase like; ornithine decarboxylase paralog; Ornithine decarboxylase-like protein; ornithine decarboxylase-paralog
Gene Aliases: ADC; AZI2; AZIB1; AZIN2; KIAA1945; ODC-p; ODC1L; ODCP
UniProt ID: (Human) Q96A70
Entrez Gene ID: (Human) 113451
spermatogenesis
putrescine transport
putrescine biosynthetic process from ornithine
negative regulation of protein catabolic process
positive regulation of catalytic activity
agmatine biosynthetic process
trans-Golgi network membrane organization
positive regulation of polyamine transmembrane transport
Performance Guarantee
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