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ADORA3 Antibody (PA5-102048) in IHC (P)
Immunohistochemistry analysis of ADORA3 in mouse muscle tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with ADORA3 polyclonal antibody (Product # PA5-102048) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-102048
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ADORA3(Accession P0DMS8), corresponding to amino acid residues Y284-E318.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2851478
Product Specific Information
Antibody detects endogenous levels of total ADORA3.
Target Information
Adenosine is involved in a variety of processes, including the synthesis of urea, the anti-inflammatory response and the inhibition of protein synthesis The adenosine receptors, including adenosine A1-R, adenosine A2A-R, adenosine A2B-R and adenosine A3-R, are integral membrane proteins that are members of the G protein-coupled receptor family. The A1-R protein mediates ureagenesis in a partially calcium-dependent manner. Adenosine is known to mediate coronary vasodilation via the A2A-R receptor. Collagen synthesis and total protein synthesis are inhibited in certain cells by adenosine, acting via the A2B receptors. Activation of the A3-R receptor inhibits the induction of the cytokine TNF alpha and blocks the endotoxin CD14 receptor signal transduction pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AD026; Adenosine A3-R; Adenosine receptor A3; BA552M11.5; G-protein coupled receptor 2; RP11-552M11.7
Gene Aliases: A3AR; A3R; AA3R; ADORA3; ARA3; Gpcr2
UniProt ID: (Human) P0DMS8
Entrez Gene ID: (Human) 140, (Mouse) 11542
adenosine receptor signaling pathway
histamine secretion by mast cell
positive regulation of leukocyte migration
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of mast cell degranulation
positive regulation of inflammatory response
positive regulation of calcium-mediated signaling
positive regulation of mucus secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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