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ADRA2A Polyclonal Antibody

ADRA2A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ADRA2A Antibody (14266-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 14266-1-AP ( ADRA2A Antibody) at dilution of 1:100 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

14266-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ADRA2A Fusion Protein Ag5562 (221-377 aa encoded by BC050414)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QIAKRRTRV PPSRRGPDAV AAPPGGTERR PNGLGPERSA GPGGAEAEPL PTQLNGAPGE PAPAGPRDTD ALDLEESSSS DHAERPPGPR RPERGPRGKG KARASQVKPG DSLPRRGPGA TGIGTPAAGP GEERVGAAKA SRWRGRQNRE KRFTFVLA (221-377 aa encoded by BC050414)

Target Information

Alpha-2-adrenergic receptors (ADRA2A) are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. ADRA2A mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G protein. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A.

Nature chemical biology

Zhao X,Stein KR,Chen V,Griffin ME,Lairson LL,Hang HC

Sun Oct 01 00:00:00 EDT 2023

SNHG15, a p53-regulated lncRNA, suppresses cisplatin-induced apoptosis and ROS accumulation through the miR-335-3p/ZNF32 axis.

American journal of cancer research

Sun YF,Wang Y,Li XD,Wang H

Thu Mar 10 00:00:00 EST 2022

Two-hour acute restraint stress facilitates escape behavior and learning outcomes through the activation of the Cdk5/GR P S211 pathway in male mice.

Experimental neurology

Wang B,Yang X,Lu J,Ntim M,Xia M,Kundu S,Jiang R,Chen D,Wang Y,Yang JY,Li S

Mon Aug 01 00:00:00 EDT 2022

Local activation of α2 adrenergic receptors is required for vagus nerve stimulation induced motor cortical plasticity.

Scientific reports

Tseng CT,Gaulding SJ,Dancel CLE,Thorn CA

Thu Nov 04 00:00:00 EDT 2021

The α2AR/Caveolin-1/p38MAPK/NF-κB axis explains dexmedetomidine protection against lung injury following intestinal ischaemia-reperfusion.

Journal of cellular and molecular medicine

Xu L,Li T,Chen Q,Liu Z,Chen Y,Hu K,Zhang X

Thu Jun 10 00:00:00 EDT 2021

Chronic Administrations of Guanfacine on Mesocortical Catecholaminergic and Thalamocortical Glutamatergic Transmissions.

International journal of molecular sciences

Fukuyama K,Nakano T,Shiroyama T,Okada M

Fri Apr 16 00:00:00 EDT 2021

β2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental Osteoarthritis.

Frontiers in immunology

Rösch G,Muschter D,Taheri S,El Bagdadi K,Dorn C,Meurer A,Zaucke F,Schilling AF,Grässel S,Straub RH,Jenei-Lanzl Z

Wed Feb 23 00:00:00 EST 2022

Sympathetic innervation contributes to perineural invasion of salivary adenoid cystic carcinoma via the β2-adrenergic receptor.

OncoTargets and therapy

Ma C,Gao T,Ju J,Zhang Y,Ni Q,Li Y,Zhao Z,Chai J,Yang X,Sun M

Fri Apr 08 00:00:00 EDT 2022

Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral Nerve Injury.

Frontiers in molecular neuroscience

Wang YJ,Zuo ZX,Wu C,Liu L,Feng ZH,Li XY

Wed Sep 30 00:00:00 EDT 2020

Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral Nerve Injury.

Frontiers in molecular neuroscience

Wang YJ,Zuo ZX,Wu C,Liu L,Feng ZH,Li XY

Wed Sep 30 00:00:00 EDT 2020

Transcription Factor CREM Mediates High Glucose Response in Cardiomyocytes and in a Male Mouse Model of Prolonged Hyperglycemia.

Endocrinology

Barbati SA,Colussi C,Bacci L,Aiello A,Re A,Stigliano E,Isidori AM,Grassi C,Pontecorvi A,Farsetti A,Gaetano C,Nanni S

Sat Jul 01 00:00:00 EDT 2017

Transcription Factor CREM Mediates High Glucose Response in Cardiomyocytes and in a Male Mouse Model of Prolonged Hyperglycemia.

Endocrinology

Barbati SA,Colussi C,Bacci L,Aiello A,Re A,Stigliano E,Isidori AM,Grassi C,Pontecorvi A,Farsetti A,Gaetano C,Nanni S

Sat Jul 01 00:00:00 EDT 2017

Effects of α2A Adrenoceptors on Norepinephrine Secretion from the Locus Coeruleus during Chronic Stress-Induced Depression.

Frontiers in neuroscience

Wang B,Wang Y,Wu Q,Huang HP,Li S

Wed Sep 30 00:00:00 EDT 2020

Effects of α2A Adrenoceptors on Norepinephrine Secretion from the Locus Coeruleus during Chronic Stress-Induced Depression.

Frontiers in neuroscience

Wang B,Wang Y,Wu Q,Huang HP,Li S

Wed Sep 30 00:00:00 EDT 2020

Bioinformatics

Protein Aliases: adrenergic receptor, alpha 2a; adrenergic, alpha-2A-, receptor; Alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type; Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; alpha-2AAR; alpha-2AAR subtype C10; Alpha-2D adrenergic receptor; alpha2A-adrenergic receptor; CA2-47; OTTHUMP00000058849; subtype alpha2-C10

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Gene Aliases: Adra-2; Adra-2a; ADRA2; ADRA2A; ADRA2R; ADRAR; alpha(2A)AR; alpha2-C10; alpha2A; alpha2A-AR; ALPHA2AAR; AW122659; CA2-47; RATRG20; RG20; ZNF32

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UniProt ID: (Human) P08913, (Mouse) Q01338, (Rat) P22909

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Entrez Gene ID: (Human) 150, (Mouse) 11551, (Rat) 25083

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Function(s)

alpha2-adrenergic receptor activity protein binding protein kinase binding alpha-1B adrenergic receptor binding alpha-2C adrenergic receptor binding thioesterase binding heterotrimeric G-protein binding protein homodimerization activity protein heterodimerization activity epinephrine binding norepinephrine binding adrenergic receptor activity G-protein coupled receptor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ADRA2A Polyclonal Antibody

ADRA2A Antibody (14266-1-AP) in IHC (P)

Product Details

14266-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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